【摘要】 目的观察国产艾司西酞普兰对安装永久性起搏器合并焦虑状态患者的治疗效果,并观察其安全性及对起搏参数的影响。方法将78例安装起搏器术后合并焦虑状态患者随机分为对照组(38例)和治疗组(40例),两组患者均给予常规药物治疗加心理干预,治疗组患者加用国产艾司西酞普兰10mg、每早1次,两组患者于安装起搏器术后24h内,治疗1周、2周及4周进行焦虑自评量表(SAS)评分,采用不良反应量表观察药物的安全性,并观察对起搏器参数的影响。结果焦虑自评量表评分治疗前,两组比较差异无统计学(P>0.05)。对照组SAS评分治疗1周较治疗前降低,差异无统计学意义(P>0.05),但治疗2周[(49.76±5.49)分比(56.15±5.09)分,P <0.01],治疗4周[(46.68±5.92)分比(56.15±5.09)分,P <0.01]均较治疗前显著下降。治疗组SAS评分治疗1周[(56.60±5.60)分比(57.35±5.23)分,P <0.05],治疗2周[(44.93±5.92)分比(57.35±5.23)分,P <0.01],治疗4周[(39.03±7.21)分比(57.35±5.23)分,P <0.01]均较治疗前显著下降。而且,治疗组SAS评分治疗2周[(44.93±5.92)分比(49.76±5.49)分,P <0.05],治疗4周[(39.03±7.21)分比(46.68±5.92)分,P <0.01]均较对照组显著下降。治疗前、治疗1周、治疗2周及治疗4周,R波振幅、心室起搏阈值、心室阻抗两组比较,差异均无统计学差异(均P>0.05)。治疗4周两组均无肝肾功能异常及心电图Q-T间期延长发生,不良反应发生率两组比较差异无统计学意义(P>0.05)。结论植入起搏器合并焦虑状态患者服用国产艾司西酞普兰在心理干预基础上可以进一步改善患者的焦虑状态,对起搏器参数无明显影响,且服药是安全的。更多还原

【Abstract】 Objective AIM To study the efficacy and safety of Chinese Escitalopram on treating patients of Cardiac Pacemaker Implanted with Anxiety Disorder,and to observe the Influence on parameters of the pacemaker.Methods We enrolled 78 patients with cardiac pacemaker implanted admitted to our hospital with Anxiety Disorder.All patients were randomized to either control group(n =38)or treatment group(n =40)for 4weeks,Both two groups were given conventional treatment combined with psychological intervention,Escitalopram tablets of 10 mg were added to treatment group every morning.Self-rating Anxiety scale(SAS)of the patients was performed in 24 hours post-operation and at 1,2,4weeks respectively.The Treatment Emergent Symptom Scale(TESS)was used to evaluate the adverse reactions.Parameters of the pacemaker were observed.Results After one-week treatment,the SAS score was(56.60±5.60)score in treatment group,(55.05±5.43)score in control group in which the difference was no significant(P >0.05).After two-week treatment,the SAS score was(44.93±5.92)score in treatment group,(49.76±5.49)score in control group in which the difference was significant(P <0.05).After four-week treatment,the SAS score was(39.03±7.21)score in treatment group,(46.68±5.92)score in control group in which the difference was significant(P <0.01).There were no significant difference in threshold value,impedance,perception and safety both two groups.Conclusion Chinese Escitalopram combined with psychological intervention can significantly improve anxiety state in Cardiac Pacemaker Implanted patients with anxiety,however safety and influence on parameters of the pacemaker was similar between the two groups.更多还原