【摘要】 目的探讨与胶质母细胞瘤(GBM)生存预后相关的影响因素。方法回顾性分析61例GBM病人的临床资料,统计分析性别、年龄、病变部位、病程时间、术前Karnofsky评分(KPS)、肿瘤残余体积、同步放化疗、MGMT表达、Ki-67表达、对疾病认知情况对病人生存期的影响。结果 61例病人生存时间为2~42个月,中位数为10个月,1、2、5年生存率分别为26.2%、9.2%、0。术前KPS评分≥70分、完成同步放化疗及Ⅳ级认知程度病人生存期较长,差异有统计学意义(P<0.05)。术前KPS评分、是否同步放化疗、病人对疾病的认知程度是影响GBM病人预后的独立因素。结论手术是治疗GBM不可缺少的手段,术前KPS评分、是否完成同步放化疗及病人对病情的认知程度可影响生存期,认知程度转化、心理辅导的必要性及对生存期的影响有待进一步研究。更多还原

【Abstract】 Objective To investigate the factors influencing survival prognosis in patients with glioblastoma(GBM). Methods Clinical data of 61 GBM patients were analyzed retrospectively. The factors influencing the survival time such as gender, age, lesion site, disease duration, preoperative Karnofsky performance scale(KPS) score, tumor residual volume, concurrent radiochemotherapy,MGMT expression, Ki-67 expression and prognostic awareness were analyzed statistically. Results The median survival time of 61 patients was 10 months, ranged from 2 to 42 months, and the 1-, 2-and 5-years survival rates were 26.2%, 9.2% and 0 respectively.The survival time was longer in the patients with preoperative KPS score more than and equal to 70, accomplishment of concurrent radiochemotherapy and level Ⅳ prognostic awareness, and the difference was found having statistical significance( P < 0. 05).Moreover, the preoperative KPS score, concurrent radiochemotherapy and prognostic awareness were the independent factors influencing on the prognosis of GBM patients. Conclusions Surgery is a necessary method for GBM. These factors as preoperative KPS score, concurrent radiochemotherapy and prognostic awareness condition can affect the survival time. The shift of prognostic awareness, the importance of psychological guidance and the influence on patients’ survival time need further research.更多还原