【摘要】 目的探讨WHOⅡ和Ⅲ级弥漫性胶质细胞瘤病人肿瘤相关性癫(tumor-associated epilepsy,TAE)与异柠檬酸脱氢酶1(IDH1)基因突变的关系。方法回顾性分析135例WHOⅡ和Ⅲ级弥漫性胶质细胞瘤病人的临床资料,统计分析肿瘤位置、年龄、性别、WHO分级、IDH1突变情况对术前癫发作的影响。结果与年龄>40岁、IDH1野生型比较,年龄≤40岁、IDH1突变型者TAE发生率高,差异有统计学意义(P<0.05)。IDH1突变型是病人术前癫发作情况的独立影响因素(OR=8.433,95%CI:3.539~20.096,P=0.000)。结论 IDH1突变型弥漫性胶质细胞瘤更易引起病人癫发作,对于WHOⅡ和Ⅲ级弥漫性胶质细胞瘤病人的治疗和预后具有重要意义。更多还原

【Abstract】 Objective To investigate the correlation between isocitrate denydrogenase 1( IDH1) gene mutant and tumorassociated epilepsy(TAE) in diffuse gliomas patients with WHO grades Ⅱ and Ⅲ. Methods Clinical data of 135 diffuse glioma patients with WHO grades Ⅱ and Ⅲ were analyzed retrospectively. The influences of lesion site, age, gender, WHO grade, IDH1 mutant type on the preoperative seizures were analyzed statistically. Results The incidence of TAE was higher in the patients with age equal to and less than 40 years and IDH1 mutant type than in the patients with age more than 40 years and IDH1 wide type(P < 0.05).The IDH1 mutant type was the independent factor for preoperative epilepsy(OR = 8.433, 95%CI: 3.539 to 20.096, P = 0.000).Conclusions The diffuse gliomas with IDH1 mutant type are more prone to cause seizure, which have important significance for the treatment and prognosis of gliomas with WHO grades Ⅱ and Ⅲ.更多还原