【摘要】 综述近30年关于羟基磷灰石（HAP）表面蛋白质吸附研究的主要工作,包括吸附的机制、影响因素及与之相关的应用研究。HAP表面蛋白质吸附的机制主要包括静电引力、氢键和范德华力,影响因素包括HAP的暴露晶面、比表面积、吸附环境中PO₄^3-和Ca²⁺的浓度、pH和温度等因素。最后介绍HAP表面蛋白质吸附在药物缓释载体及骨组织工程支架领域的应用研究,为探索HAP的生物活性及特殊吸附功能的设计提供全面、准确的借鉴。更多还原

【Abstract】 This paper summarized the research progress of protein adsorption on hydroxyapatite（HAP） in the past 30 years, including adsorption mechanism, crucial factors and related application exploration. The adsorption mechanisms include electrostatic attraction, hydrogen bond and van der Waals force. The crucial factors include exposing crystal faces of HAP, specific surface area, concentration of PO₄^3- and Ca²⁺, pH and temperature in the adsorption environment. In addition, this article introduced the application research of protein adsorption on HAP in the field of drug sustained-release carrier and bone tissue engineering scaffold. This review aimed to provide comprehensive introduction of advances for exploring the biological activity and special adsorption function design of HAP.更多还原