【摘要】 目的探究尿石清合剂治疗下焦湿热型患者的作用机制。方法 120例下焦湿热型尿路结石患者,随机分为对照组和试验组,每组60例。两组患者均采用超细经皮肾镜取石术(SMP)进行治疗,对照组术后给予排石颗粒口服,试验组术后给予尿石清合剂,持续治疗60 d,比较两组患者中医证候改善情况、治疗后不良反应及随访12个月复发情况。结果试验组证候改善总有效率95.00%(57/60)显著高于对照组的81.67%(49/60),差异具有统计学意义(χ~2=5.1752,P=0.0229<0.05)。两组患者治疗期间均未见任何严重不良反应,仅对照组出现1例轻微恶心,对治疗无影响,未处理,在3 d内自行消失。两组患者均获得随访,随访时间12个月,试验组复发率1.67%稍低于对照组8.33%,但差异无统计学意义(χ~2=2.8070,P=0.0938>0.05)。结论下焦湿热型患者经SMP治疗术后使用尿石清合剂,可显著改善中医证候,而且安全性较好,复发风险较小。更多还原

【Abstract】 Objective To investigate the mechanism of Niao Shi Qing mixture in the treatment of lowerjiao damp-heat type patients.Methods A total of 120 lower-jiao damp-heat type patients were randomly divided into control group and experimental group,60 cases in each group.Patients in two groups were given super-minimally invasive percutaneous nephrolithotomy(SMP) for treatment.The control group was given Pai Shi granule for oral administration,and the experimental group was given Niao Shi Qing mixture after surgery.After 60 days of continuous treatment,the improvement of TCM syndromes,adverse reactions after treatment and recurrence after 12 months of follow-up were compared between the two groups.Results The total effective rate of the experimental group was 95.00%(57/60),which was significantly higher than 81.67%(49/60) of the control group,and the difference was statistically significant(χ~2=5.1752,P=0.0229<0.05).No serious adverse reactions were found during the treatment of the two groups.Only 1 case of mild nausea in the control group had no effect on the treatment and was not treated and disappeared within 3 d.Patients of two groups were followed up for 12 months,and recurrence rate of the experimental group was 1.67%,which was slightly lower than 8.33% of the control group,but the difference was not statistically significant(χ~2=2.8070,P=0.0938>0.05).Conclusion The application of Niao Shi Qing mixture after SMP treatment in patients with lower-jiao damp-heat type can significantly improve TCM syndromes,and has better safety and less recurrence risk.更多还原