【摘要】 MCR-1主要作用是介导肠杆菌科细菌对多粘菌素产生抗药性,其基因mcr-1由1626个碱基组成,其中鸟嘌呤和胞嘧啶的含量约占了一半。根据实验推断mcr-1基因所翻译出来的是一段具有介导磷酸乙醇胺转移作用的酶,由541个氨基酸组成。菌株可携带完整的ISApl1或ISApl1片段。mcr-1是质粒上的一段基因,介导多粘菌素类药物耐药,但它并不耐受目前所有的抗生素。mcr-1耐药机制是其整合于质粒,可以随着质粒在不同细菌中水平传播,甚至可以与其他的耐药基因共同存在于单一质粒,表达后产生多种耐药机制。本文就mcr-1的发现、流行、耐药性等方面的研究进展进行简要综述。更多还原

【Abstract】 The main role of MCR-1 is to mediate polymyxin resistance in Enterobacteriaceae. mcr-1 is 1626 bp in size and the content of guanine and cytosine accounts for about half. According to previous study, mcr-1 translates an enzyme that mediates the transfer of phosphoethanolamine and consists of 541 amino acids. The host bacteria of mcr-1 can harbor the intact or truncated ISApl1 element. mcr-1 is a plasmid-carrying gene but not a new bacterial variant; it only mediates polymyxin resistance, but not to all current antibiotics. The mcr-1 can be integrated into plasmid, which mediates its horizontal transfer in different bacteria. It can even coexist with other drug resistance genes in a single plasmid, and a variety of drug resistance phenotype are generated after expression. In this paper, the discovery, prevalence and drug resistance of mcr-1 are briefly reviewed.更多还原