目的:检测急性冠脉综合征(acute coronary syndrome,ACS)患者相关血清生物标志物水平,探讨其对颈动脉斑块稳定性评价的临床意义。方法:选择2016年1月至2017年12月本院心血管内科收治的ACS患者90例,根据颈动脉超声检查结果将患者分为易损斑块组(51例)和稳定斑块组(39例),另选45例未见粥样硬化斑块者为对照组。ELISA法检测3组血清高敏C反应蛋白(high-sensitivity C reactive protein,hs-CRP)、正五聚蛋白-3(pentraxin-3,PTX-3)、妊娠相关性蛋白-A(pregnancy related protein-A,PAPP-A)、脂蛋白相关的磷脂酶A2(lipoprotein related phospholipase A2,Lp-PLA2)及氧化型低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)水平。结果:观察组血清所有指标水平均明显高于正常对照组(P<0.05)。易损斑块组血清PTX-3、PAPP-A、Lp-PLA2及ox-LDL水平明显高于稳定斑块组(P<0.05)。Logis...
【英文摘要】
Objective:To detect the levels of serum biomarkers in acute coronary syndrome(ACS)patients and to explore the significance of the detection for evaluating carotid plaque stability. Methods :Totally 90 patients with ACS were selected from the cardiovascular department in our hospital during January 2016 and December 2017. The ACS patients were divided into the vulnerable plaque group(51 cases)and the stable plaque group(39 cases),according to the results of carotid ultrasonography. Forty-five healthy people,...
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