【摘要】 目的:探讨血糖、血脂及其他临床因素与腹主动脉瘤(AAA)腔内血栓(ILT)的关系。方法:回顾性分析中国医科大学附属第一医院血管外科2014年7月—2017年10月收治的151例AAA患者资料,运用统计学方法分析与AAA中ILT的相关因素。结果:151例AAA患者中,有ILT者132例,无ILT者19例。与非ILT组比较,ILT组的男性患者比例及周围动脉疾病患者比例增高,以及甘油三酯(TG)、肌酐(Cr)、D-二聚体(D-D)水平明显升高(均P<0.05)。ILT厚度方面,男性患者ILT厚度明显高于女性,有糖尿病(DM)患者ILT厚度小于无DM患者(均P<0.05);按ILT厚度分组比较显示,薄ILT组AAA瘤径明显小于厚ILT组,DM患者比例及空腹血糖(FBG)浓度高于厚ILT组,而总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、D-D水平则低于厚ILT组(均P<0.05)。相关分析提示,ILT厚度与TC(r=0.206,P=0.018)及LDL-C(r=0.227,P=0.009)均呈正相关。结论:血脂是ILT产生和发展的重要因素,血糖及DM对ILT的影响仍然需要进一步探索。更多还原

【Abstract】 Objective: To investigate the relations of blood glucose and lipid as well as other factors with the intraluminal thrombus(ILT) in abdominal aortic aneurysm(AAA) patients.Methods: The clinical data of 151 AAA patients treated in the Department of Vascular Surgery of the First Affiliated Hospital of China Medical University from July 2014 to October 2017 were analyzed retrospectively. The factors associated with ILT in AAA were determined by using statistical methods. Results: Of the 151 patients, 132 cases were found having ILT and 19 cases without ILT. In patients with ILT compared with those without ILT, the proportions of male cases and cases with peripheral artery disease were elevated, and the levels of triglyceride(TG), creatinine(Cr) and D-dimer(D-D) were increased(all P<0.05).As for the ILT thickness, the ILT thickness in male patients was greater than that in female patients, and patients with diabetes mellitus(DM) was less than that in patients without DM(both P<0.05); the results of grouped comparison according to the ILT thickness showed that the aneurysm diameter of AAA was smaller, the proportion of DM cases and the fasting blood-glucose(FBG) level were higher, the levels of total cholesterol(TC), low density lipoprotein cholesterol(LDL-C) and D-D were lower in thin ILT group than those in thick ILT group(all P<0.05). Correlation analysis shows that the ILT thickness were positively correlated with TC(r=0.206, P=0.018) and LDL-C(r=0.227, P=0.009).Conclusion: Blood lipid is an important factor for the occurrence and development of ILT, while the impacts of blood glucose and DM on ILT still need to be further explored.更多还原