【摘要】 目的分析1990和2013年福建省恶性肿瘤疾病负担和变化情况,为恶性肿瘤防治策略的制定提供科学依据。方法利用2013年全球疾病负担研究(GBD2013)中国福建省恶性肿瘤数据资料,描述1990和2013年福建省恶性肿瘤的疾病负担,主要指标包括死亡数、过早死亡损失寿命年(YLL)、伤残损失寿命年(YLD)和伤残调整寿命年(DALY),使用GBD2013全球标准人口计算标化死亡率、标化YLL率、标化YLD率和标化DALY率,并计算1990到2013年疾病负担指标的变化率。结果 2013年福建省恶性肿瘤死亡人数为64 387例,较1990年增加了57.5%,差异有统计学意义(P<0.05);而标化死亡率为184.18/10万,较1990年下降了13.9%,差异无统计学意义(P>0.05)。2013年恶性肿瘤造成的DALY、YLL、YLD分别是163.37万人年、159.88万人年和34.97千人年,与1990年相比,分别显著上升了35.7%、34.5%和120.6%,差异均有统计学意义(P<0.05)。2013年恶性肿瘤的标化DALY率、标化YLL率和标化YLD率分别是4 275.97/10万、4 180.92/10万和95.05/10万,与1990年相比,恶性肿瘤的标化DALY率和标化YLL率分别显著下降了22.6%和23.3%,而标化YLD率显著上升了23.1%。按照DALY排序,2013年福建省居于前5位的恶性肿瘤依次是肝癌,气管、支气管和肺癌,胃癌,食道癌以及结肠和直肠癌。与1990年相比,DALY上升较快的恶性肿瘤为前列腺癌,乳腺癌,胰腺癌,结肠和直肠癌,气管、支气管和肺癌以及多发性骨髓瘤。结论恶性肿瘤是福建省居民的主要疾病负担,应重点加强对肝癌,气管、支气管和肺癌,胃癌,前列腺癌和乳腺癌的防控。更多还原

【Abstract】 Objective To analyze the disease burden of malignant tumors in Fujian Province in 1990 and 2013, and to provide the basis for the strategy of prevention of malignant tumors. Methods The deaths, years of life lost(YLL), years lived with disability(YLD) and disability-adjusted life-years(DALY) of malignant tumors in Fujian Province were analyzed using the Fujian Province-specific data in China from the Global Burden of Disease study in 2013(GBD2013). The world standard population used for GBD 2013 was used to calculate the standardized mortality, YLL rate, YLD rate and DALY rate. The change rates of these indicators were calculated from 1990 to 2013. Results In 2013, 64 387 residents died from malignant tumors in Fujian Province,which increased by 57.5% compared with that in 1990(P<0.05); the standardized mortality of malignant tumors was 184.18/100 000,which decreased by 13.9% compared with that in 1990(P<0.05); the DALY, YLL and YLD resulted from malignant tumors were163.37 million person years, 159.88 million person years and 34.97 thousand person years respectively, which significantly increased by 35.7%, 34.5% and 120.6% respectively, compared with those in 1990(P<0.05); the standardized DALY rate, YLL rate and YLD rate of malignant tumors were 4 275.97/100 000, 4 180.92/100 000 and 95.05/100 000 respectively, the standardized DALY rate and YLL rate of malignant tumors significantly decreased by 22.6% and 23.3%, but the standardized YLD rate increased significantly by 23.1%, compared with those in 1990. According to DALY, the order of the first five malignant tumors in 2013 were liver cancer, tracheal, bronchus, and lung cancer, stomach cancer, esophageal cancer, colon and rectal cancer. Compared with 1990, the DALYs of prostate cancer, breast cancer, pancreatic cancer, colon and rectum cancer, tracheal,bronchus, and lung cancer, multiple myeloma increased rapidly. Conclusion Malignant tumors were the main disease burden of Fujian residents, the prevention and control measures should focus on liver cancer, tracheal, bronchus, and lung cancer, stomach cancer, prostate cancer and breast cancer.更多还原