【摘要】 第177期双清论坛"中西医结合防治代谢性疾病的关键科学问题"围绕代谢性疾病的中西医理论研究进展、新技术与新方法以及针对代谢性疾病的药物研究展开了深入研讨,与会专家一致认为机体代谢紊乱是众多慢性、多基因复杂性疾病,包括心脑血管、神经精神系统、肿瘤、骨质疏松等共同病理基础,中医药在调整恢复机体代谢内稳态中具有突出优势。论坛主要从主要从以下5个方面,凝练了中西医结合防治代谢性疾病的关键科学问题:(1)代谢性疾病中西医理论的融合与发展,(2)基因、环境、饮食等复杂因素扰动代谢与重大疾病发生发展,(3)生理、病理状态下肠肝代谢调控规律与机理,(4)基于代谢调控节点的药物靶标发现,(5)代谢性疾病的药物发现与干预。然而,目前关于代谢性疾病的中西医理论融合、研究方法学及药物研究策略等相关研究遇到瓶颈,通过多学科交叉、中西医融合的途径,组织全国相关领域的专家学者开展深入的协同创新研究,将有望走出一条具有中医特色、融汇现代科技的创新之路。更多还原

【Abstract】 The 177 th Shuangqing Forum sponsored by National Natural Science Foundation of China entitled"The Key Scientific Issues in the Prevention and Treatment of Metabolic Diseases with Integrative Chinese and Western Medicine"was held in Beijing,China during May 11—12,2017.More than 30 experts and scholars from 28 institutes,universities and hospitals attended this forum.These experts and scholars focus on their researches about traditional Chinese medicine,Chinese materia medica,basic medicine,clinical medicine,biology and so on.The major topics in preventing and treating metabolic diseases by integrative Chinese and Western medicine have been discussed in depth,including research progress of theory,the emerging of new method and technology,and drug research and development.Finally,all attendees reached a consensus that metabolic disorders are the common pathology fundamentals of a number of chronic,multi-gene regulated,complex diseases,including cardiovascular disease,cerebrovascular disease,neuropsychiatric system disorder,cancer,osteoporosis,and so on.It was concluded that Chinese medicine has the outstanding advantages in the adjustment and recovery of the metabolic homeostasis.However,there are still bottleneck problems in the integration of the theories about Chinese and Western medicine for metabolic diseases,as well as research methodologies and drug research strategies.Finally,the key scientific issues were concentrated on five aspects,including:(1)Integrate and development of the theory about Chinese medicine and western medicine in metabolic diseases;(2)The genesis and development of serious disease which was related to the complicated disturbs such as genes,environment and diet;(3)The rules and mechanisms of enterohepatic metabolism under physiological and pathological conditions;(4)Discovery of drug targets from the key molecules in the regulation of metabolism;(5)Prevention of metabolism diseases and discovery of related drugs.By interdisciplinary research and integration of traditional Chinese and Western medicine,experts and scholars organized from all over the country are carrying out collaborative innovation research in-depth,thus,we will carve out the innovative ways with the characteristics of Chinese medicine and integration of modern science and technology.更多还原