【摘要】 该文综述灵芝抗衰老与抗阿尔茨海默病的药理研究进展。灵芝多糖可显著改善老年小鼠的免疫功能,使降低的空斑形成细胞反应、T和B淋巴细胞的增殖反应、混合淋巴细胞反应以及白介素-2生成恢复至接近正常水平,这一作用与灵芝多糖增强老年小鼠脾细胞的DNA多聚酶α活性有关。灵芝多糖通过抗氧化应激可延缓细胞、器官和组织的衰老。灵芝多糖、三萜以及灵芝孢子粉可改善阿尔茨海默病动物模型的学习与记忆功能和海马的组织病理学损伤,其机制与灵芝的抗氧化清除自由基作用密切相关。更多还原

【Abstract】 Present article reviewed the pharmacological progress on anti-aging and antiAlzheimer’s disease of Ganoderma(Lingzhi). G.lucidum polysaccharide significantly enhanced the immunity in aged mice,which involved that increasing plaque forming cells,promoting T and B lymphocyte proliferation reaction and mixed lymphocyte reaction,and enhancing interleukin-2 production in aged mice. The immune-enhancing effect of G.lucidum polysaccharides may relate to increase DNA polymeraseαactivity of spleen cells in aged mice. G.lucidum polysaccharide can delay the aging of cells,organs and tissues by anti-oxidative stress. G. lucidum polysaccharides,triterpenes and spores can improve of learning and memory function and histopathological injury of the hippocampus in animal model of Alzheimer disease,and its mechanism is closely related to antioxidative and scavenging free radicals effect by Ganoderma(Lingzhi).更多还原