【摘要】 目的对晚期宫颈癌局部近距离放疗期间医院感染及阴道粘连患者的临床特点进行分析。方法选择2015年5月-2016年12月期间收治的480例中晚期宫颈癌患者,根据病情采取不同剂量的局部放射治疗,对所有患者的临床资料进行回顾性分析,分析患者放疗后感染的发生率、发生部位及相关影响因素;探讨放疗后患者阴道粘连与阴道微生态情况的相关性。结果 480例中晚期宫颈癌放疗后的患者中,发生感染88例,感染率为18.33%,感染以膀胱感染和肠道感染为主;年龄、治疗时长、肿瘤分类、肿瘤分期、内外照射总剂量是中晚期宫颈癌患者放疗后发生感染的独立影响因素;480例患者中,发生阴道粘连45例,发生率为9.4%,发生阴道粘连的45例患者中,阴道微生态失调患者36例占80.00%,阴道粘连患者阴道微生态失调的发生率高于未发生阴道粘连患者(χ2=8.185,P=0.003)。结论年龄、治疗时长、肿瘤分类、肿瘤分期、内外照射总剂量是中晚期宫颈癌患者放疗期间发生感染的独立影响因素。调节患者阴道微生态平衡是预防放射治疗阴道粘连的关键。更多还原

【Abstract】 OBJECTIVE To observe the clinical characteristics of patients with nosocomial infections and vaginal adhesions during short-range radiotherapy for locally advanced cervical cancer.METHODS A total of 480 patients with advanced cervical cancer who were treated in the hospital from May 2015 to Dec 2016 were enrolled in the study,the different doses of local radiotherapies were carried out according to the illness condition,the clinical data of all the patients were retrospectively analyzed,the incidence of infection,infection sites and related influencing factors were observed after the radiotherapies.The correlation between the vaginal adhesions and vaginal microecological status was observed.RESULTS Of the 480 advanced cervical cancer patients undergoing the radiotherapies,88 had infections,with the infection rate 18.33%,and the patients with bladder infection and intestinal infection were dominant.The independent influencing factors for the infections in the patients with advanced cervical cancer after radiotherapy included the age,long time of treatment,types of tumors,stage of tumors and total dose of internal and external radiation.Of the 480 patients,45 had vaginal adhesions,with the incidence rate 9.4%;among the 45 patients with vaginal adhesions,36(80.00%)had vaginal microflora imbalance,and the incidence rate of vaginal microflora imbalance of the patients with vaginal adhesions was significantly higher than that of the patients without vaginal adhesions(χ2=8.185,P=0.003).CONCLUSIONThe independent influencing factors for the infection in the patients with advanced cervical cancer during the radiotherapy include the age,long time of treatment,types of tumors,stage of tumors and total dose of internal and external radiation.It is the key to regulate the vaginal microecological balance so as to prevent the vaginal adhesions from radiotherapy.更多还原