【摘要】 目的研究迷迭香精油、水溶性提取物与脂溶性提取物对东莨菪碱所致学习记忆障碍模型小鼠学习记忆能力的影响。方法构建东莨菪碱所致的学习记忆障碍小鼠模型,通过跳台试验、避暗实验和Y迷宫实验观察迷迭香不同提取物对小鼠学习记忆的改善作用。结果迷迭香精油、水溶性提取物和脂溶性提取物均可使记忆障碍模型小鼠跳台潜伏期延长和错误次数减少(P<0.01);避暗潜伏期延长、错误次数减少(P<0.01);Y迷宫正确次数明显增加(P<0.01)。结论迷迭香精油、水溶性提取物和脂溶性提取物能够改善东莨菪碱所致学习记忆障碍模型小鼠的学习记忆功能。更多还原

【Abstract】 Objective To investigate the effect of Rosemary essential oil, water soluble extract and lipid soluble extract on learning and memory ability in memory acquisition impairment model mice induced by scopolamine. Methods Memory acquisition impairment mice model induced by scopolamine was established, and the step-down test, dark-avoidance test and Y-Maze test were used to observe the effect of different extracts of Rosemary on learning and memory in mice. Results Rosemary essential oil, water soluble extract and lipid soluble extract also could prolong latency and decrease the number of errors in the step-down test and dark-avoidance test(P<0.01), significantly increase the number of corrects in Y-Maze test(P<0.01). Conclusion Rosemary essential oil, water soluble extract and lipid soluble extract can improve learning and memory function in memory acquisition impairment model mice induced by scopolamine.更多还原