【摘要】 目的探讨乳腺癌合并2型糖尿病患者的病情进展情况和预后分析。方法选取2015年1月至2016年7月间华中科技大学同济医学院附属梨园医院收治的150例女性乳腺癌患者进行回顾性研究,合并2型糖尿病者为观察组,未合并糖尿病者为对照组,每组75例。比较两组患者产次、原发性肿瘤直径、淋巴结转移情况、肿瘤浸润率指标和孕激素受体、雌激素受体阴性表达率及人表皮生长因子阳性表达率。结果两组患者的原发性肿瘤直径比较,差异无统计学意义(P>0.05)。观察组患者淋巴结3枚以上转移率为33.3%,高于对照组的12.0%,观察组患者Ⅲ级肿瘤浸润率为46.7%,高于对照组的22.7%,两组比较,差异均有统计学意义(均P<0.05)。观察组患者ER阴性表达率(58.7%)高于对照组(41.3%),PR阴性表达率(61.3%)高于对照组(44.0%);HER-2阳性表达率(66.7%)高于对照组(45.3%),两组比较,差异均有统计学意义(均P<0.05)。结论乳腺癌合并2型糖尿病患者病情较为严重,预后差,病死率高。伴有2型糖尿病可能是诱发乳腺癌患者预后不良的关键因素。更多还原

【Abstract】 Objective To study the disease progression and prognosis in patients with breast cancer complicated with type 2 diabetes. Methods A total of 150 female breast cancer patients admitted to Liyuan Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology from January2015 to July 2016 were retrospectively analyzed. Among them,patients with breast cancer complicated with type 2 diabetes were included in the observation group,and patients with breast cancer wihout type 2 diabetes were included in the control group with 75 patients in each group. Production time,primary tumor size,lymph node metastasis,tumor infiltration rate,estrogen and progesterone receptors( ER and PR) negative expression rate and human epidermal growth factor( HER-2) positive expression rate were compared between the two groups. Results There was no statistically significant difference in primary tumor size between the two groups( P > 0. 05). The lymphatic metastasis( more than 3 lymph nodes) rate was 33. 3%for the observation group which was significantly higher than 12. 0% in the control group( P < 0. 05). The grade Ⅲ tumor infiltration rate was 46. 7% for the observation group which was higher than 22. 7% of the control group( all P < 0. 05). The negative expression of ER in the observation group( 58. 7%) was significantly higher than 41. 3% of the control group,the negative expression of PR in the observation group( 61. 3%) was higher than in the control group( 44. 0%),and the positive expression of HER-2 was higher in the observation group( 66. 7%) than in the control group( 45. 3%)( all P < 0. 05). Conclusion Patients with breast cancer complicated with type 2 diabetes have severe disease,poor prognosis and high mortality. Type 2 diabetes may be the key factor leading to poor prognosis in patients with breast cancer.更多还原