【摘要】 目的探讨胃肠道间质瘤患者小肠细菌过度生长(SIBO)情况及其临床病理特点。方法选取2015年6月至2017年6月间青岛市市立医院收治的52例胃肠道间质瘤(GIST)患者为GIST组,另选取同期30例健康体检者为对照组。采用葡萄糖氢呼气试验(GHBT)检测术前GIST患者及健康对照者的SIBO情况,对患者肿瘤标本进行组织病理学检查和术后危险度分级。结果 GIST患者SIBO阳性率(53.8%)明显高于健康者(16.7%),差异有统计学意义(P<0.05)。GIST发生于胃者35例,发生于小肠者12例,发生于十二指肠者5例。肿瘤危险度分级:极低危10例、低危15例、中危7例和高危20例。免疫组化CD117、CD34、DOG-1、SMA、S-100和Ki-67阳性表达率分别为96.2%、65.4%、90.4%、7.7%、3.9%和34.6%。结论胃肠道间质瘤患者较健康者易发生SIBO,临床表现缺乏特异性,CD117、CD34和DOG-1在胃肠道间质瘤的诊断中具有较高的价值。更多还原

【Abstract】 Objective To investigate the intestinal bacterial overgrowth( SIBO) and the clinicopathological features in patients with gastrointestinal stromal tumors( GIST) and its clinicopathological features. Methods The clinical data of 52 patients with GIST were collected at Qingdao Municipal Hospital from June 2015 to June 2017. Another 30 individuals who had physical examination were selected ast the same as the control group. Glucose hydrogen breath test( GHBT) was used to detect preoperative SIBO in patients with GIST and the healthy controls. Histopathological examination of tumor specimens and grading of postoperative risk were performed. Results The positive rate of SIBO in patients with GIST( 53. 8%)was significantly higher than that in the healthy subjects( 16. 7%)( P < 0. 05). GIST occurred in the stomach in 35 patients,occurred in small intestine in 12 patients and in duodenum in 5 patients. The classification of the risk degree of the tumors: very low risk in 10 patients( low risk in 15 patients,moderate risk in 7 patients and high risk in 20 patients. The positive expression rates of immunohistochemistry CD117,CD34,DOG-1,SMA,S-100 and Ki-67 were 96. 2%,65. 4%,90. 4%,7. 7%,3. 9% and 34. 6%. Conclusion Gastrointestinal stromal tumors are more likely to occur in SIBO than healthy people. The clinical manifestations of gastrointestinal stromal tumors are lack of specificity. The value of CD117,CD34 and DOG-1 were high in the diagnosis of GIST.更多还原