【摘要】 目的分析C-erbB-2、Bmi-1和COX-2在大肠癌及癌旁正常组织中的表达,探讨其与临床病理特征的关系。方法选取本院2014年1月1日至2016年12月31日收治并经病理证实的68例大肠癌患者的癌变组织作为观察组,另选同期癌旁正常组织(距癌灶>10cm)20例作为对照组。采用免疫组织化学方法检测两组组织中的C-erbB-2、Bmi-1和COX-2表达情况,并分析其与大肠癌临床病理特征的关系。结果免疫组化检测显示,C-erb B-2、Bmi-1、COX-2大肠癌组织中的表达明显高于癌旁正常组织(P<0.05),三者在不同组织分化程度、Dukes分期、淋巴结转移、浸润深度中的癌变组织中均存在明显差异(P<0.05),而三者的表达与性别、年龄、部位、大小无关(P>0.05);C-erbB-2、Bmi-1、COX-2表达相互间呈显著正相关(P<0.05)。结论 C-erbB-2、Bmi-1和COX-2表达与组织分化程度、Dukes分期、淋巴结转移、浸润深度相关,可作为临床判定大肠癌恶性程度及预后评估的指标。更多还原

【Abstract】 Objective To investigate the expression of C-erbB-2, Bmi-1 and COX-2 in 68 cases of colorectal carcinoma were detected by immunohistochemical staining and to analyze its relationship with clinical pathological characteristics and mutual relations. Method Expression of C-erbB-2, Bmi-1 and COX-2 in 68 cases of colorectal carcinoma were detected by immunohistochemical staining and to analyze its relationship with clinical pathological characteristics and mutual relations. Result Immunohistochemical detection showed that C-erbB-2、Bmi-1 and COX-2 expression in colorectal carcinoma tissues increased significantly(P<0.05), the three were in different degree of tissue differentiation, Dukes staging, lymph node metastasis, invasion depth of obvious difference(P<0.05), while the expression of the three had nothing to do with the gender, age, position, size(P>0.05), C-erbB-2, Bmi-1 and COX-2 expression was significantly positive correlation between each other(P<0.05). Conclusion C-erbB-2, Bmi-1 and COX-2 expression and tissue differentiation, Dukes staging, lymph node metastases, infiltrating depth could be used as a clinical decision colorectal malignant degree and the evaluation of prognosis indicator.更多还原