【摘要】 目的:考察非离子型聚丙烯酰胺（型号:NPAM 1400）单用及与纳米微粉硅胶（nSiO₂）联用对甘草次酸脂化乳稳定性的影响。方法:采用紫外-可见分光光度计,分别测定脂化乳离心前后稀释液在500 nm波长处的吸光度,以未加入稳定辅料的制剂为空白计算稳定性系数（K_E）和稳定性系数之比(K_E/K_E空白),评价加入不同浓度（200⁶00 mg/L）非离子型聚丙烯酰胺对甘草次酸脂化乳稳定性的影响,初步确定单用最佳浓度后,再考察其与不同浓度的n SiO₂[亲水性（0.2%、0.3%、0.4%）和疏水性（0.2%、0.3%、0.5%）]联用对甘草次酸脂化乳稳定性的影响。结果:单用时,加入300 mg/L非离子型聚丙烯酰胺的甘草次酸脂化乳的KE最小,K_E/K_E空白为0.22;联用时,加入300 mg/L非离子型聚丙烯酰胺+0.2%疏水性n SiO₂的甘草次酸脂化乳的KE最小,K_E/K_E空白为0.27。结论:单用非离子型聚丙烯酰胺及与n SiO₂联用均可在一定程度上提升甘草次酸脂化乳的稳定性,其中单用300 mg/L非离子型聚丙烯酰胺效果最佳。更多还原

【Abstract】 OBJECTIVE:To investigate the effects of non-ionic polyacrylamide（model:NPAM 1400）alone or combined with nanoscale silica gel（n SiO₂）on the stability of Glycyrrhetinic acid lipo-emulsion. METHODS:UV-spectrophotometer was used to determine absorbance of diluent at 500 nm before and after lipo-emulsion centrifugation. Using the preparation without stable excipient as blank,stability coefficient（K_E）and it ratio(K_E/K_{E blank})were calculated. Effects of different concentrations（200-600 mg/L）of non-ionic polyacrylamide on the stability of Glycyrrhetinic acid lipo-emulsion were evaluated. The optimal concentration of non-ionic polyacrylamide alone was determined primarily,and then the effects of it combined with different concentrations of hydrophilic n SiO₂（0.2%,0.3%,0.4%） or hydrophobic（0.2%,0.3%,0.5%） on the stability of Glycyrrhetinic acid lipo-emulsion were investigated. RESULTS:When adding non-ionic polyacrylamide alone,K_Eof Glycyrrhetinic acid lipo-emulsion mixed with 300 mg/L non-ionic polyacrylamide was the lowest,K_E/K_{E blank}was 0.22;when combined,K_Eof Glycyrrhetinic acid lipo-emulsion mixed with 300 mg/L non-ionic polyacrylamide and 0.2% hydrophobic n SiO₂ was the lowest,K_E/K_{E blank}was 0.27.CONCLUSIONS:Non-ionic polyacrylamide alone or combined with n SiO₂ all can promote the stability of Glycyrrhetinic acid lipo-emulsion,among which 300 mg/L non-ionic polyacrylamide alone is the best.更多还原