【摘要】 目的:研究耐碳青霉烯类鲍曼不动杆菌(CRAB)感染的危险因素,为临床预防其感染提供参考。方法:采用回顾性研究,收集我院2012年12月-2017年6月鲍曼不动杆菌(AB)感染患者302例,根据药敏试验结果将患者分为CRAB组(116例)和非CRAB组(186例)。采用单因素分析发生CRAB感染的危险因素,并对两组间有显著性差异的变量进行多因素Logistic回归分析。结果:单因素分析发现,两组患者比较,有显著性差异的因素包括分离出AB前出现感染性休克(P=0.003)、脓毒症(P=0.000)、合并其他感染(P=0.006)以及患有糖尿病(P=0.029)、恶性肿瘤(P=0.036),患有除肺部、腹内、皮肤感染外的其他部位感染(P=0.009),分离出AB前28 d使用碳青霉烯类药物(P=0.002)和抗真菌类药物(P=0.002)。多因素Logistic回归分析显示,两组患者比较,有显著性差异的因素包括分离出AB前出现脓毒症(P=0.033)和患有糖尿病(P=0.011)。结论:分离出AB前患者出现脓毒症以及患有糖尿病为CRAB感染的独立危险因素。更多还原

【Abstract】 OBJECTIVE:To study risk factors for carbapenem-resistant Acinetobacter baumannii(CRAB) infection,and to provide reference for its clinical prevention. METHODS:In retrospective study,302 A. baumannii(AB) infection patients were collected from our hospital during Dec. 2012 to Jun. 2017. According to the results of drug sensitivity test,those patients were divided into CRAB group(116 cases)and non-CRAB group(186 cases). Risk factors for CRAB infection were analyzed by using univariate analysis. Multivariate Logistic regression analysis was performed for variables with significant difference between 2 groups. RESULTS:Univariate analysis showed that the factors of significant difference in 2 groups including patients suffering from septic shock(P=0.003),sepsis(P=0.000),combined with other infection(P=0.006),diabetes(P=0.029),malignant tumors(P=0.036),patients suffering from infection of other site except for pulmonary infection,intraabdominal infection and skin infection(P=0.009) before AB isolation,patients given carbapenems(P=0.002) and antifungal drugs 28 d before AB isolation(P=0.002). Multivariate Logistic regression analysis showed that the factors of significant difference in 2 groups including patients suffering from sepsis(P=0.033) or diabetes(P=0.011) before AB isolation. CONCLUSIONS:Independent risk factors for CRAB infection include patients suffer from sepsis or diabetes before AB isolation.更多还原