【摘要】 目的探讨双歧杆菌三联活菌胶囊制剂辅助治疗对新诊断2型糖尿病(T2DM)患者肠道双歧杆菌及胰岛素抵抗的影响。方法 86例新诊断T2DM患者随机分为两组。两组均给予饮食调整和适量运动等基础治疗。对照组给予阿卡波糖联合甘精胰岛素控制血糖;观察组在对照组基础上加用双歧杆菌三联活菌胶囊制剂630mg/次,2次/d,温水口服,连用12周。观察两组患者治疗前与治疗12周后血糖达标情况、肠道双歧杆菌数量及胰岛素抵抗的变化。结果治疗12周后,观察组患者空腹血糖(FBG)、餐后2h血糖(2hPG)和糖化血红蛋白(HbA1C)的达标率较对照组更高(P<0.05);两组患者肠道双歧杆菌数量与胰岛素抵抗指数(HOMA-IR)水平分别较前明显上升和下降,且观察组变化更显著(P<0.05)。结论双歧杆菌三联活菌胶囊制剂辅助治疗新诊断T2DM不仅能增加患者肠道双歧杆菌的数量,而且能改善胰岛素抵抗,有利于血糖和糖化血红蛋白达标。更多还原

【Abstract】 Objective To discuss the influence of Bifid Triple Viable Capsules as adjuvant therapy(AT)on gut Bifidobacteriumand insulin resistance function of patients with new diagnosed type 2 diabetes mellitus(T2 DM).Methods 86 cases of patients with new diagnosed T2 DM were randomly divided into observation group and control group.The patients in two groups were given diet adjustment,reasonable exercise and other basic medical treatment.The patients in control group were given Acarbose combined with insulin glargine to control blood sugar,while the patients in observation group were additionally given 630 mg Bifid Triple Viable Capsules per time,twice a day,with warm boiled water,for 12 weeks.The changes of blood sugar to reach target,gut Bifidobacteriumand insulin resistance of patients in two groups before and after12 weeks′treatment were observed.Results After 12 weeks′treatment,the target control rates of fasting blood-glucose(FBG),2 hour post-prandial glucose(2 hPG)and hemoglobin Alc(HbA1 C)of patients in observation group were much higher than those in control group(P<0.05).The gut Bifidobacteriumand Homeostatic Model Assessment for Insulin Resistance(HOMA-IR)in two groups were obviously increased and declined than before respectively,and the changing rates of patients in observation group were much higher than those in control group(P<0.05).Conclusion The application of Bifid Triple Viable Capsules as AT on the treatment of patients with new diagnosed T2 DM,can increase the quantity of gut Bifidobacteriumand improve insulin resistance to be advantageous for the target of blood sugar and glycosylated hemoglobin.更多还原