【摘要】 幽门螺杆菌(Helicobacter pylori,H.pylori)是一种革兰阴性杆菌,于1893年首次从慢性活动性胃炎患者的胃黏膜活检组织中被成功分离培养,是目前所知的少数能够在人胃中生存的微生物之一。H.pylori感染不仅可引起胃炎、消化道溃疡、胃黏膜组织相关性(MALT)淋巴瘤等消化系统疾病,其所携带的毒力因子还与胃癌的发生发展有关。不同基因型的H.pylori所携带的毒力因子不同,但只有小部分的感染个体会进展为胃癌的现象。虽然目前诸如CagA、VacA、BabA和OipA等许多毒力因子都已被证明与胃癌的发生有确切关系,但其具体机制仍在进一步的研究当中。本文将主要针对H.pylori中与胃癌相关的毒力因子及其致癌机制进行简要综述,以进一步明确其在胃癌发生发展中的生物学作用。更多还原

【Abstract】 H.pylori is a Gram-negative bacterium,which was first isolated from the gastric mucosa of a patient who was diagnosed as chronic active gastritis in 1893.Currently it is one of the few microorganisms that can inhabit in human stomach.Infection with H.pylori can arouse many gastroduodenal diseases such as gastritis and peptic ulcer,and the virulence factors of H.pylori are associated with the development of gastric carcinoma.H.pylori with different genotypes has different virulence factors,but only a minority of H.pylori-infected patients will finally suffer from gastric cancer.Although many virulence factors like Cag PAI,VacA,OMPs and OipA have been proved to be involved in gastric cancer,the exact mechanisms are still poorly understood.In this review,we discussed the virulence factors of H.pylori and their role in the development of gastric carcinoma,in order to define these factors′biological roles.更多还原