【摘要】 目的了解黄芪阿胶补铁口服液改善缺铁性贫血的效果。方法选取74只大鼠,采用缺铁性饲料方法建立大鼠贫血模型,取造型成功动物,据血红蛋白(Hb)水平,采用随机区组法分成低、中、高3个样品剂量组和低铁对照组,分别按3.33 ml/kg BW、6.67 ml/kg BW和20.0 ml/kg BW和去离子水给予大鼠灌胃32 d。观察比较大鼠体重、血红蛋白(Hb)、红细胞压积(Hct)和红细胞游离原卟啉(FEP)。结果大鼠体重与低铁对照组比较,差异均无统计学意义(P>0.05),黄芪阿胶补铁口服液3个剂量组的血红蛋白(Hb)(F=161.156)和红细胞压积(Hct)(F=78.771)均显著高于低铁对照组(P<0.05),红细胞游离原卟啉(FEP)值(F=170.516)均显著低于低铁对照组,差异均有统计学意义(P<0.05)。结论黄芪阿胶补铁口服液具有改善缺铁性贫血的功能。更多还原

【Abstract】 Objective To get known the effect of Huangqi Ejiao Butie Oral Solution in improving iron-deficiency anemia. Methods Seventy-four rats were selected. The an animal model of anemia using iron-deficiency diet was established. These rat models were divided into the low-, medium-, and high-dose sample groups and low-iron group by random block based on the hemoglobin(Hb) level, 3.33 ml/kg BW, 6.67 ml/kg BW and 20.0 ml/kg BW, and deionized water for 32-day intragastric administration in turn. The rats′ weight, Hb, hematocrit(Hct) and free erythrocyte protoporphyrin(FEP) were observed. Results There was no significant difference in rat body weight in these sample groups compared with low-iron control group(P>0.05). The Hb(F=161.156) and Hct(F=78.771) in the three dose groups using Huangqi Ejiao Butie Oral Solution were significantly higher than those in the low-iron control group(P<0.05). The value of FEP(F=170.516) was significantly lower compared with that in the low-iron control group, the differences were statistically significant(P<0.05). Conclusion Huangqi Ejiao Butie Oral Solution can improve iron-deficiency anemia.更多还原