Objective To investigate the association between adenosine triphosphate-binding cassette transporter G2(ABCG2) gene polymorphism and uric acid level among gout patients in tropical areas and to provide evidences for the warning, diagnosis, and treatment of gout. Methods Totally 572 gout patients(317 males and 255 females) living in Hainan province were selected at Haikou Municipal People's Hospital from January 2014 to December 2016 and assigned into a hyperuricemia group and a normal uric acid group accord...
【基金】
海口市重点科技计划项目(2015–32)
【更新日期】
2018-07-23
【分类号】
R589.7
【正文快照】
尿酸是体内嘌呤分解代谢的终产物,其沉积于关节会导致痛风症的发生[1]。尿酸盐转运系统是影响尿酸排泄功能的重要因素,部分研究显示其基因的突变可能与患者体内尿酸浓度的升高及痛风的发生密切相关[2–3]。三磷酸腺苷结合转运蛋白G2(adenosine triphosphate-binding cassette t
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