【摘要】 目的已有流行病学研究探讨了精细谷物的摄入量和冠心病发病风险的关系,但是结果并不一致。本文运用剂量反应Meta分析方法对精细谷物的摄入量与冠心病发病风险的关系进行分析,以期得到可靠的结果。方法收集国内外从发表到2018年1月以来有关精细谷物摄入量与冠心病发病风险的文献,通过STATE 12. 0软件,采用随机效应模型估计效应值,用限制性立方样条探讨其剂量反应关系。结果研究结果显示,摄入高剂量的精细谷物较低剂量能够增加冠心病的发病风险(RR=1. 10,95%CI:1. 01～1. 21,Z=1. 98,P=0. 045,I2=11. 2%)。对纳入研究的地理位置进行亚组分析,发现高剂量的精细谷物仅在亚洲地区对冠心病的发病风险有意义(RR=1. 79,95%CI:1. 02～3. 16,Z=2. 01,P=0. 043,I2=0),在美洲和欧洲地区无意义。剂量反应关系结果显示,精细谷物的摄入量和冠心病的发病风险有一种线性关系,精细谷物摄入量每增加1 serving/week,冠心病的发病风险将增加0. 2%(RR=1. 00,95%CI:1. 00～1. 01,P=0. 38),但结果尚无统计学意义。结论高剂量的精细谷物摄入相对于低剂量可能会增加冠心病的发病风险,尤其对于亚洲人群。更多还原

【Abstract】 Objective Using a dose-response meta-analysis to obtain a reliable results of the relationship between dietary refined grain intake and the risk of coronary heart disease(CHD). Epidemiological studies have explored the relationship between refined grain intake and the risk of CHD,but the results are inconsistent so far. Methods Literatures on fine grain intake and the risk of CHD published until January 2018 were collected. The effects were estimated by random effect model with STATE 12. 0 software,and the dose-response relationship was assessed by restricted cubic spline. Results The results showed that intake of high-dose refined grains could increase the risk of CHD compared with low-dose refined grains(RR =1. 10,95% CI: 1. 01-1. 21,Z = 1. 98,P = 0. 045,I2= 11. 2%). Subgroup analysis of the geographical locations included in the study revealed that high doses of refined grains were significant for the risk of CHD only in Asia(RR = 1. 79,95% CI:1. 02-3. 16,Z = 2. 01,P = 0. 043,I2= 0),but not in America and Europe. The dose-response relationship showed that there was a linear relationship between the intake of refined grains and the risk of CHD. The risk of CHD increased by0. 2%(RR = 1. 00,95% CI: 1. 00-1. 01,P = 0. 38) with an increase of 1 serving/week,but the results had no statistically significant. Conclusion High doses of refined grains intake may increase the risk of CHD compared with low doses of refiend grains,especially in Asian populations.更多还原