【摘要】 目的探讨抗信号识别颗粒抗体阳性肌病的临床、病理及治疗。方法对8例抗信号识别颗粒抗体阳性肌病的临床资料、实验室检查及治疗情况进行分析总结。结果 8例患者男性1例,女性7例,平均年龄37.5岁,肌酸激酶平均4888.6U/L,抗SRP抗体阳性,肌肉病理提示可见坏死和再生的肌纤维,无或少量的炎性细胞存在,少部分可出现肥大和萎缩的肌纤维。结论抗信号识别颗粒抗体阳性肌病是一种抗信号识别颗粒抗体阳性的免疫介导坏死性肌病,由于该病对激素治疗的反应性不完全,易复发,因此确诊是关键。更多还原

【Abstract】 Objective To investigate the clinical,pathological and therapeutic analysis of anti-signal particle antibody positive myopathy.Methods The clinical data,laboratory tests and treatment of 8 cases of antibody-positive myopathy were identified and analyzed.Results There were 1 males and 7 females in 8 cases,with an average age of 37.5 years.The average creatine kinase was 4888.6 U/L.The anti-SRP antibody was positive.Muscle pathology showed necrotic and regenerated myofibers without or with a few inflammatory cells.A small number of hypertrophy and atrophy of the muscle fibers may appear.Conclusion Anti-signal-particle antibody-positive myopathy is a kind of immune-mediated necrotizing myopathy that is positive for anti-signal particle antibody.Because of its incomplete reactivity to hormone therapy,it is easy to relapse,so diagnosis is the key.更多还原