【摘要】 目的观察热疗联合胸腔内顺铂化疗治疗晚期肺腺癌恶性胸腔积液的疗效与安全性。方法将61例晚期肺腺癌合并恶性胸腔积液患者随机分成两组,研究组31例给予胸腔积液置管引流后灌注顺铂化疗及局部胸腔热疗,对照组30例接受胸腔积液置管引流后单纯胸腔内灌注顺铂化疗,比较两组患者的临床疗效及不良反应,并采用KPS评分评价患者的生活质量。结果研究组胸腔积液控制客观有效率明显高于对照组(87.1%vs 60.0%,P<0.05),生活质量的总改善率亦明显优于对照组(83.9%vs 56.7%,P<0.05)。两组毒性反应率比较无统计学差异(P>0.05)。结论胸腔热疗联合胸腔内灌注顺铂化疗治疗晚期肺腺癌合并恶性胸腔积液疗效确切,毒副反应轻,能有效改善患者生活质量。更多还原

【Abstract】 Objective To observe the efficacy and safety of hyperthermia combined with cisplatin for chemotherapy in the treatment of advanced lung adenocarcinoma complicated with malignant pleural effusion.Methods 61 patients with advanced lung adenocarcinoma complicated with malignant pleural effusion were randomly divided into two groups.31 patients in the study group were given perfusion of cisplatin for chemotherapy and local pleural hyperthermia after catheterization and drainage of pleural effusion.30 patients in the control group were given pleural effusion with cisplatin alone after catheterization and drainage of pleural effusion.The clinical efficacy and adverse reactions were compared between the two groups,and KPS scores were used to evaluate the quality of life of patients.Results The objective effective rates of the control of pleural effusion in the study group were significantly higher than those in the control group(87.1% vs 60.0%,P<0.05).The overall improvement rate of quality of life was also significantly better than the control group(83.9% vs 56.7%,P<0.05).There was no statistically significant difference in the rate of toxic reactions between the two groups(P>0.05).Conclusion Thoracic hyperthermia combined with intrapleural effusion of cisplatin for chemotherapy in the treatment of advanced lung adenocarcinoma complicated with malignant pleural effusion has an exact curative effect,and the toxic reactions are mild,which can effectively improve the quality of life of patients.更多还原