【摘要】 目的研究静态调强技术和容积旋转调强治疗技术在治疗鼻咽癌时对海马区的物理剂量学的差异性。方法对2016年5~11月入院的10例鼻咽癌患者采用:(1)容积旋转调强治疗技术V-MAT-HF(对海马区有剂量限制);(2)容积旋转调强治疗技术V-MAT(对海马区不作剂量限制);(3)9野静态调强计划9B-IMRT-HF(对海马区有剂量限制);(4)9野静态调强计划9B-IMRT(对海马区不作剂量限制),记录各患者靶区适形性CI、剂量均匀性HI脑海马区HF的放射剂量,统计剂量学差异。结果鼻咽癌患者靶区容积旋转调强技术(保护脑海马区)对脑海马区的剂量低于其他三种治疗技术,其差异有统计学意义(P<0.05);行保护性照射的容积调强技术对脑海马区HF受照剂量远远低于其他三种治疗技术,差异有统计学意义(P<0.05)。结论 10例鼻咽癌患者靶区容积旋转调强技术(保护脑海马区)对脑海马区的剂量明显低于其他三种治疗技术,VMAT保护海马区技术可以认为是鼻咽癌患者放射治疗的首选治疗技术。更多还原

【Abstract】 Objective To study the differences of physical dosimetry and biological indicators of hippocampus in the treatment of nasopharyngeal carcinoma by different volumetric modulated arc therapies(V-MAT). Methods(1)V-MATHF(dose-limiting for hippocampus),(2)V-MAT(no dose-limiting for hippocampus),(3) 9-field intensity modulated radiation therapy-HF(9 B-IMRT-HF)(dose-limiting for hippocampus) and(4)9 B-IMRT(no dose limitation for hippocampus) were used in 10 cases of nasopharyngeal carcinoma admitted from May 2016 to November 2016 in our hospital.Conformal index(CI), Homogeneity index(HI) and radiation dose of HF in brainstem, spinal cord and hippocampus were recorded. Results The doses of V-MAT-HF(dose-limiting for hippocampus) to the hippocampus in patients with nasopharyngeal carcinoma were significantly lower than those of the other three therapeutic techniques(P<0.05); HF dose to hippocampus of V-MAT with protective radiation was much lower than the other three techniques(P<0.05). Conclusion The dose of V-MAT(protecting the hippocampus) of 10 patients with nasopharyngeal carcinoma is significantly lower than that of the other three therapeutic techniques. V-MAT which protects hippocampus can be considered as the preferred treatment of radiation therapy for patients with nasopharyngeal carcinoma.更多还原