【摘要】 目的研究黄花蒿Artemisia annua全草大极性部位的化学成分。方法采用Sephadex LH-20柱色谱、硅胶柱色谱、ODS柱色谱和制备薄层色谱等方法进行分离纯化,根据波谱数据确定化合物的结构。结果从黄花蒿70%乙醇冷浸提取物的甲醇可溶部位中共分离得到14个化合物,分别鉴定为黄花蒿苷A(1)、东莨菪苷(2)、2,4-二羟基-6-甲氧基苯乙酮-4-O-β-D-吡喃葡萄糖苷(3)、咖啡酸甲酯(4)、水杨酸(5)、阿魏酸(6)、香草酸(7)、2,4-二羟基-6-甲氧基苯乙酮(8)、高圣草酚(9)、棕鳞矢车菊黄酮素(10)、penduletin(11)、甲氧基寿菊素(12)、圣草酚(13)和(R)-15,16-didehydrocoriolic acid(14)。结论化合物1为未见文献报道的新香豆素苷;化合物14为首次从蒿属植物中分离得到;化合物9为首次从黄花蒿中得到。更多还原

【Abstract】 Objective To study the chemical constituents with high polarity from the whole herb of Artemisia annua. Methods The constituents were isolated and purified by column chromatography on Sephadex LH-20, silica gel, ODS, and preparative TLC. The structures were elucidated by the analysis of the spectroscopic data. Results Fourteen compounds were obtained from the methanol soluble fraction of the 70% ethanol extract of A. annua by maceration at room temperature and identified as artemisiannuside A(1), scopolin(2), 2,4-dihydroxy-6-methoxyacetophenone-4-O-β-D-glucopyranoside(3), methyl caffeate(4), salicylic acid(5), ferulic acid(6), vanillic acid(7), 2,4-dihydroxy-6-methoxyacetophenone(8), homoeriodictyol(9), jaceidin(10), penduletin(11), axillarin(12), eriodictyol(13), and(R)-15,16-didehydrocoriolic acid(14), respectively. Conclusion Compound 1 is a new acylated coumarin glycoside. Compound 14 is isolated from the Artemisia genus for the first time and compound 9 is firstly isolated from A. annua.更多还原