AIM: To study the value of copeptin( CPP) level for the prediction of cardiorenal syndrome( CRS) in the rats with subtotal nephrectomy( SNX) combined with myocardial infarction( MI). METHODS: Male SD rats( n = 60) were divided into blank control group( Con group),renal failure group( SNX group),heart failure group( MI group) and heart failure + renal failure group( CRS group). The concentrations of CPP in the serum and urine,hemodynamic indexes,blood pressure and renal function indexes were measured 1 ~ 5 w...