AIM: To evaluate the effect of exogenous hydrogen sulfide( H_2S) on the expression of NLRP3 inflammasome in hepatocytes. METHODS: The hepatocytes L02 and SMMC-7721 were used to establish the model of inflammation by stimulating with lipopolysaccharide( LPS) at different concentrations in vitro. The expression of NLRP3 inflammasome in the hepatocytes was detected by Western blot and the cell viability was measured by MTT assay for determining appropriate concentration of LPS. The hepatocytes were divided int...