【摘要】 目的探索经颅重复高频磁刺激(rTMS)治疗孤独症谱系障碍(ASD)儿童的有效性。方法采用临床对照试验。选取20例3~6岁ASD儿童为研究组:rTMS+结构化教育(TEACCH)。同期招募与研究组性别、年龄相匹配的20例ASD儿童为对照组(TEACCH)。2组儿童的康复周期均持续6个月。使用孤独症治疗评估量表(ATEC)比较干预前、后改变情况。结果干预后,两组的AETC量表总分及分量表得分差异均有统计学意义(P均<0.05)。研究组与对照组干预前后ATEC量表总分和各分量表差异均有统计学意义(P均<0.05)。结论 ASD儿童经过持续半年的rTMS+TEACCH或单一的TEACCH课程,其主要临床表现均有较显著改善;rTMS+TEACCH的联合干预方案,其康复效果更佳。更多还原

【Abstract】 Objective To explore the effect of comprehensive rehabilitation intervention with deep repetitive transcranial magnetic stimulation( rTMS) among autism spectrum disorder( ASD) children. Method Controlled clinical trial was used. A total of 20 3-6 years old ASD children who treated by rTMS and structured teaching( TEACCH) were selected as the intervention group. And,20 ASD children whose sex and age-matched with intervention group and treated only by TEACCH were recruited as the control group. All of those children were recovering 6 months The curative effect of the control group and intervention group was compared. Result After intervention,there were significant difference in total scale and subscales score between the intervention group and the control group( P< 0. 05). Before and after intervention,the difference of ATEC scale total score was statistically significant( P < 0. 05) between the two groups. Conclusion There are significantly improvements of the main clinical manifestations among ASD children through the training by rTMS combined with TEACCH or TEACCH. The rehabilitation effect of rTMS combined with TEACCH is much better.更多还原