【摘要】 1例63岁男性患者,服用瑞舒伐他汀钙片的同时加用依折麦布片;约1周后感觉手关节疼痛;继续服药至1个月左右,膝关节疼痛难忍,无法行走;停药1周后,关节疼痛症状完全消失,期间瑞舒伐他汀钙片未间断服用。瑞舒伐他汀在该不良反应发生前、中、后均未停药,持续服用,因此,该不良反应的发生与依折麦布的使用时间关系明确。药品说明书显示:关节疼痛为依折麦布不常见的不良反应。该案例依折麦布致关节疼痛的关联性为"很可能"。提示临床上遇到患者服药期间不明原因的关节疼痛时,应首先排除药品不良反应。更多还原

【Abstract】 A 63-year-old male patient was given Rosuvastatin calcium tablets combined with Ezetimibe tablets; after 1 week, the patient felt arthralgia in hands; at about 1-month continuous administration, the symptom of arthralgia became unbearable and the patient could not walk; at 1 week after drug withdrawl, the symptoms of arthralgia had disappeared completely, while the administartion of Rosuvastatin calcium tablets was not interrupted. The patient was constantly given Rosuvastatin calcium tablets at before, during and after the occurrence of adverse drug reactions. Therefore, the occurrence of adverse drug reactions was clearly related to the application of ezetimibe. The dispensatory indicates that arthralgia is an uncommon adverse drug reaction of ezetimibe. In this case, the association between arthralgia and ezetimibe is "very likely". It is suggested that when the patient encounters an unexplained arthralgia during medication, the adverse drug reaction should be excluded first.更多还原