【摘要】 目的:探讨比阿培南用于重症感染患者的给药方案优化方法。方法:选取2015年3月至2016年3月常州市第一人民医院收治的重症感染患者70例,以随机数字表法分为观察组40例和对照组30例。采用蒙特卡罗法拟合不同给药方案,得到药效学目标值较优的两种给药方案。即对照组患者给予比阿培南0.3 g,每6 h给药1次,静脉滴注,30 min滴毕;观察组患者给予比阿培南0.3 g,每8 h给药1次,微泵输注3 h。比较两组患者的临床疗效、细菌清除情况、比阿培南平均用药时间、比阿培南人均费用及不良反应发生情况。结果:观察组、对照组患者总有效率分别为65.0%(26/40)、63.3%(19/30),差异无统计学意义(P>0.05);观察组、对照组患者细菌清除率分别为27.5%(11/40)、20.0%(6/30),差异无统计学意义(P>0.05);观察组患者比阿培南平均用药时间为(6.23±2.50)d,明显短于对照组的(8.40±3.95)d,差异有统计学意义(P<0.05);观察组患者比阿培南人均费用为(3 762±2 054)元,明显少于对照组的(5 571±2 938)元,差异有统计学意义(P<0.05);两组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:重症感染患者比阿培南3 h泵入给药的疗效优于常规30 min静脉滴注给药,且用药量较少,疗程较短,费用较少。更多还原

【Abstract】 OBJECTIVE: To probe into the optimization method of administration of biapenem in patients with severe infection. METHODS: 70 patients with severe infection admitted into the First People’s Hospital of Changzhou from Mar. 2015 to Mar. 2016 were extracted to be divided into observation group( 40 cases) and control group( 30 cases) via the random number table. Monte Carlo method was used to fit different administration regimens to obtain two regimens with better pharmacodynamic target values. The control group was given biapenem of 0. 3 g,administration was provided in once every 6 hours with intravenous drip for 30 min; while the observation group received biapenem of 0. 3 g,administration was provided in once every 8 hours with micropump infusion for 3 h. The clinical efficacy,bacterial clearance,mean administration time,mean cost and incidence of adverse drug reactions of two groups were compared. RESULTS: The total effective rate of observation group and control group were respectively65. 0%( 26/40) and 63. 3%( 19/30),without any statistically significant difference( P > 0. 05). The bacterial clearance of observation group and control group were respectively 27. 5%( 11/40) and 20. 0%( 6/30),without any statistically significant difference( P > 0. 05). The mean administration time of observation group was( 6. 23 ± 2. 50) d,significantly shorter than that of control group [( 8. 40 ± 3. 95) d],with statistically significant difference( P < 0. 05).The mean cost of observation group was( 3 762 ± 2 054) yuan,significantly lower than that of control group[( 5 571 ± 2 938) yuan],with statistically significant difference( P < 0. 05). There was no statistically significant difference between two groups in the incidence of adverse drug reactions( P > 0. 05). CONCLUSIONS: The efficacy of3 h pumping administration of biapenem in patients with severe infection was better than that of routine intravenous drip for 30 min,with less dosage,shorter course of treatment and less cost.更多还原