【摘要】 目的:探讨硫酸镁对急性重症胆囊炎患者血清C反应蛋白、胆红素及胃肠功能的影响。方法:选取2015年3月至2017年4月潜江市中心医院收治的急性重症胆囊炎患者90例作为研究对象,以随机数字表法分为观察组和对照组,每组45例。对照组患者给予常规治疗,观察组患者在对照组的基础上加用硫酸镁治疗。对比观察两组患者的腹痛、发热及胆囊肿大消失时间,治疗前后血清C反应蛋白、胆红素、血浆胃动素及血管活性肠肽水平,白细胞计数和中性粒细胞百分比的差异。结果:观察组患者腹痛、发热及胆囊肿大消失时间明显短于对照组;治疗后,观察组患者血清C反应蛋白、胆红素水平明显低于对照组,血浆胃动素水平明显高于对照组,血管活性肠肽水平明显低于对照组,白细胞计数、中性粒细胞百分比明显低于对照组;上述差异均有统计学意义(P<0.05)。结论:硫酸镁可有效缩短急性重症胆囊炎患者的腹痛、发热及胆囊肿大消失时间,降低患者体内炎症反应,提高胃肠功能。更多还原

【Abstract】 OBJECTIVE: To probe into the effects of magnesium sulfate on serum c-reactive protein,bilirubin and gastrointestinal function in patients with acute severe cholecystitis. METHODS: 90 patients with acute severe cholecystitis admitted into Qianjiang Central Hospital from Mar. 2015 to Apr. 2017 were selected and divided into observation group and control group via random number table,with 45 cases in each. The control group was given conventional therapy, the observation group was given magnesium sulfate combined with conventional therapy.Differences in disappearance times of stomachache,fever and gallbladder enlargement,levels of serum C-reactive protein,bilirubin,plasma motilin,vasoactive intestinal peptide,white blood cell counts and neutrophilic granulocyte percentages between two groups were observed and compared. RESULTS: The disappearance times of stomachache,fever and gallbladder enlargement of observation group were significantly shorter than those of the control group; after treatment,the C-reactive protein and bilirubin levels of observation group were significantly lower than those of the control group; the plasma motilin level of observation group was significantly higher than that of the control group,the vasoactive intestinal peptide level of observation group were significantly lower than that of the control group; the white blood cell count and neutrophilic granulocyte percentage of observation group were significantly lower than those of the control group; all above differences were statistically significant( P < 0. 05). CONCLUSIONS: Magnesium sulfate can effectively relieve stomachache,fever and gallbladder enlargement in patients with acute severe cholecystitis,reduce patients’ inflammatory reactive and improve gastrointestinal function.更多还原