【摘要】 目的:探讨不同剂量布地奈德联合沙丁胺醇雾化吸入治疗儿童哮喘急性期的疗效。方法:选取2015年2月—2017年2月武汉市第一医院收治的儿童哮喘急性期患者106例进行回顾性分析,根据治疗方法的不同分为A、B组,每组53例。A组患儿采用布地奈德0.5 mg、沙丁胺醇2.5 mg,雾化吸入,1日2次;B组患儿采用布地奈德1.0 mg、沙丁胺醇2.5 mg,雾化吸入,1日2次。观察两组患儿的临床疗效、呼吸峰流速（PEF）、第1 s用力呼气容积（FEV₁）、第1 s用力呼气容积占预计值的百分比（FEV₁%）水平及不良反应发生情况。结果:A、B组患儿的总有效率分别为94.34%（49/53）、92.45%（50/53）,差异无统计学意义（P>0.05）;治疗后,两组患儿PEF、FEV₁及FEV₁%水平明显高于治疗前,且B组患儿明显高于A组,差异均有统计学意义（P<0.05）;A、B组患儿不良反应发生率分别为9.43%（5/53）、13.21%（7/53）,差异无统计学意义（P>0.05）。结论:较大剂量布地奈德联合沙丁胺醇雾化吸入治疗儿童哮喘急性发作,可进一步改善患儿肺功能,促进患儿恢复。更多还原

【Abstract】 OBJECTIVE: To probe into the efficacy of different doses of budesonide combined with salbutamol for aerosol inhalation in treatment of acute phase of pediatric asthma. METHODS: 106 children with acute phase of pediatric asthma admitted into Wuhan No. 1 Hospital from Feb. 2015 to Feb. 2017 were retrospectively selected and divided into group A and group B according to different therapeutic regimens,with 53 cases in each. Group A was given 0. 5 mg of budesonide combined with 2. 5 mg of salbutamol for aerosol inhalation for twice a day; group B was given 1. 0 mg of budesonide combined with 2. 5 mg of salbutamol for aerosol inhalation for twice a day. Clinical efficacy,peak expiratory flow rate（ PEF）,forced expiratory volume in 1 s（ FEV₁）,the proportion of FEV₁ accounted for predicted value（ FEV₁%） and incidences of adverse drug reactions of two groups were observed. RESULTS: The total effective rate of group A and group B were respectively 94. 34%（ 49/53） and 92. 45%（ 50/53）,the difference had no statistical significance（ P > 0. 05）; after treatment,the PEF,FEV₁ and FEV₁% of both groups were significantly higher than those of before treatment,and those of group B were significantly higher than group A,with statistically significant differences（ P < 0. 05）; the incidences of adverse drug reactions of group A and group B were respectively9. 43%（ 5/53） and 13. 21%（ 7/53）,the difference had no statistical significance（ P > 0. 05）. CONCLUSIONS:Larger dose of budesonide combined with salbutamol for aerosol inhalation in treatment of acute phase of pediatric asthma can further improve pulmonary function and recovery.更多还原