【摘要】 绝经后骨质疏松症的发病机制与骨保护素(OPG)/核因子-κB受体活化因子(RANK)/核因子-κB受体活化因子配体(RANKL)系统功能紊乱密切相关。未成熟的成骨细胞分泌RANKL,RANK与其结合,刺激破骨细胞分化成熟并抑制其凋亡,从而促进骨吸收;成熟的成骨细胞分泌OPG,与RANK竞争性结合RANKL,从而抑制破骨细胞分化成熟并诱导其凋亡,降低骨吸收。中药及针刺尤其是补肾或补肾健脾的中药及穴位针刺可有效调节OPG/RANK/RANKL系统,这可能是中药及针刺防治绝经后骨质疏松症的作用机制之一。更多还原

【Abstract】 The pathogenesis of postmenopausal osteoporosis is closely related to the dysfunction of osteoprotegerin(OPG)/receptor activator of nuclear factor κB(RANK)/receptor activator of nuclear factor κB ligand(RANKL) system. Imma ture osteoblast secretes RANKL, which is combined with RANK, then it will stimulate the differentiation of osteoclast and inhibit its apoptosis, promoting bone absorption. Mature osteoblast secretes OPG, which will competitively combine RANKL with RANK, thus inhibit osteoclast differentiation and induce its apoptosis, reducing bone resorption. OPG/RANK/RANKL system can be regulated by traditional Chinese medicine and acupuncture, especially the traditional Chinese medicine and acupoints of tonifying kidney and spleen. This may be one of the mechanisms of traditional Chinese medicine and acupoints to prevent and treat postmenopausal osteoporosis.更多还原