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中药及针刺对去卵巢骨质疏松大鼠OPG/RANK/RANKL调节作用的实验研究概况

General experiment study about regulating effect on OPG/RANK/RANKL system of ovariectomized osteoporosis rats by traditional Chinese medicine and acupuncture

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【作者】 周晶莹周宁张祎雯杨弘光赵英侠

【Author】 ZHOU Jingying;ZHOU Ning;ZHANG Yiweng;YANG Hongguang;ZHAO Yingxia;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;College of Acumox and Tuina, Shanghai University of Traditional Chinese Medicine;College of Basic Medicine, Shanghai University of Traditional Chinese Medicine;Clinical Medical School of Longhua, Shanghai University of Traditional Chines Medicine;

【通讯作者】 赵英侠;

【机构】 上海中医药大学附属曙光医院上海中医药大学针灸推拿学院上海中医药大学基础医学院上海中医药大学龙华临床医学院

【摘要】 绝经后骨质疏松症的发病机制与骨保护素(OPG)/核因子-κB受体活化因子(RANK)/核因子-κB受体活化因子配体(RANKL)系统功能紊乱密切相关。未成熟的成骨细胞分泌RANKL,RANK与其结合,刺激破骨细胞分化成熟并抑制其凋亡,从而促进骨吸收;成熟的成骨细胞分泌OPG,与RANK竞争性结合RANKL,从而抑制破骨细胞分化成熟并诱导其凋亡,降低骨吸收。中药及针刺尤其是补肾或补肾健脾的中药及穴位针刺可有效调节OPG/RANK/RANKL系统,这可能是中药及针刺防治绝经后骨质疏松症的作用机制之一。

【Abstract】 The pathogenesis of postmenopausal osteoporosis is closely related to the dysfunction of osteoprotegerin(OPG)/receptor activator of nuclear factor κB(RANK)/receptor activator of nuclear factor κB ligand(RANKL) system. Imma ture osteoblast secretes RANKL, which is combined with RANK, then it will stimulate the differentiation of osteoclast and inhibit its apoptosis, promoting bone absorption. Mature osteoblast secretes OPG, which will competitively combine RANKL with RANK, thus inhibit osteoclast differentiation and induce its apoptosis, reducing bone resorption. OPG/RANK/RANKL system can be regulated by traditional Chinese medicine and acupuncture, especially the traditional Chinese medicine and acupoints of tonifying kidney and spleen. This may be one of the mechanisms of traditional Chinese medicine and acupoints to prevent and treat postmenopausal osteoporosis.

【基金】 国家基础科学人才培养基金项目资助(J1103607);上海市大学生科创项目资助(2017SHUTCM182);上海市教委预算内科研项目(08cz01);上海市教委第五期重点学科项目资助(J50301)
  • 【文献出处】 中国医药导报 ,China Medical Herald , 编辑部邮箱 ,2018年33期
  • 【分类号】R259
  • 【被引频次】5
  • 【下载频次】290
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