【摘要】 目的分析阵发性房颤(PAF)患者N端脑钠肽前体(NT-proBNP)水平和P波离散度(Pd)变化,为PAF的诊断和预后判定提供理论依据。方法收集2010年1月～2015年12月在内蒙古自治区人民医院住院的PAF患者130例作为房颤组,另选取同期健康体检者50名作为对照组。分析两组转复前后NT-proBNP水平和Pd值的变化,对PAF组患者出院后6个月进行随访,分析房颤复发与未复发患者转复前后NT-proBNP水平和Pd值的关系。结果房颤组患者转复前NT-proBNP水平明显高于对照组(P <0.05);转复后NT-proBNP水平明显低于转复前,但仍高于对照组,差异有统计学意义(P <0.05)。房颤组患者转复前Pd值显著高于对照组(P <0.05);转复后Pd值明显低于转复前(P <0.05),但与对照组比较差异无统计学意义(P> 0.05)。出院第3个月时房颤复发组患者转复前NT-proBNP水平高于房颤未复发组患者,差异有统计学意义(P <0.05)。出院第3、4、5、6个月时房颤复发组转复后NT-proBNP水平高于房颤未复发组,差异有统计学意义(P <0.05)。结论 NT-proBNP水平与Pd值对PAF患者的诊断和预后判定具有良好的应用价值。更多还原

【Abstract】 Objective To analyse the changes of N-terminal pro-brain natriuretic peptide(NT-proBNP) level and P wave dispersion(Pd) in patients with paroxysmal atrial fibrillation(PAF), and provide the reference for the diagnosis and prognosis of PAF. Methods One hundred and thirty PAF patients in Inner Mogolia People′s Hospital were selected as the atrial fibrillation group and 50 healthy physical examination people were selected as control group. The changes of NT-proBNP level and Pd value of the two groups before and after cardioversion were analyzed, patients in the atrial fibrillation group were followed up for 6 months after discharge. The relationship between the NT-proBNP level and the Pd value before and after the cardioversion of atrial fibrillation was analyzed. Results The level of NT-proBNP before cardioversion in the atrial fibrillation group was significantly higher than that in the control group(P < 0.05); the level of NT-proBNP after cardioversion in the atrial fibrillation group was lower than that before cardioversion, which was still higher than that in the control group, the differences were statistically significant(P < 0.05). The Pd value before cardioversion in the atrial fibrillation group was significantly higher than that in the control group(P < 0.05); the Pd value after cardioversion in the atrial fibrillation group was lower than that before cardioversion(P < 0.05), but it had no significant difference compared with that in the control group(P > 0.05). After diacharge for 3 months, the level of NTproBNP before cardioversion in the recurrent PAF group was higher than that in the non recurrent PAF group before cure, the difference was statistically significant(P < 0.05). After discharge for 3, 4, 5, 6 months, the level of NT-proBNP after cardioversion in the recurrent PAF group was higher than that in the non recurrent PAF group after cardioversion, the differences were statistically significant(P < 0.05). Conclusion The NT-proBNP level and Pd value have good application value for the diagnosis and prognosis of patients with PAF.更多还原