【摘要】 心血管疾病是当前威胁我国人民健康最严重的公共卫生问题。动脉粥样硬化是其主要病理基础,可发生于儿童时期,肥胖儿童患病风险增高。内质网应激是动脉粥样硬化发生发展的重要机制。肥胖的脂肪组织中巨噬细胞浸润增多,内质网应激加剧,脂肪细胞与巨噬细胞间交互作用也加速动脉粥样硬化进程,在动脉粥样硬化性心血管疾病的发生发展中起重要作用。本文就脂肪组织内质网应激与肥胖儿童动脉粥样硬化发生发展关系的相关机制进行综述,旨在加深人们对肥胖加速儿童患动脉粥样硬化疾病的理解,提高人们预防儿童肥胖的认识,并为肥胖引发的儿童动脉粥样硬化的治疗开拓新思路。更多还原

【Abstract】 Cardiovascular disease is the most serious public health problem that currently threatens the health of people in our country. Atherosclerosis is the main pathological basis and can occur in childhood, and the risk of obesity in children is increasing. Endoplasmic reticulum stress is an important mechanism for the development of atherosclerosis.Macrophage infiltration in obese adipose tissue increases, endoplasmic reticulum stress aggravates, interaction between adipocytes and macrophages accelerates atherosclerotic progression, which plays an important role in the development of atherosclerotic cardiovascular disease. For deepening people′s knowledge of obesity accelerating atherosclerosis and raising awareness of preventing childhood obesity, and exploiting new ideas for treating atherosclerosis in children with obesity, this review introduced the relationship between endoplasmic reticulum stress of adipose tissue and the development of atherosclerosis in children with obesity.更多还原