【摘要】 目的探讨25-羟维生素D3与IL-10在系统性红斑狼疮(SLE)中的临床应用。方法选取182例SLE患者为实验组,150例同期来本院体检的非SLE患者作为对照组,2组患者的性别与年龄比较无统计学差异(P>0.05),其中SLE实验组根据疾病活动性指数(SLEDAI)评分标准分为活动组(100例)和缓解组(82例)。采用ELISA方法测定实验组和对照组的血清25-羟维生素D3和IL-10水平,并比较各组的差异。结果 SLE实验组25-羟维生素D3为(17.51±8.29)ng/mL,明显低于对照组的(38.31±9.34)ng/mL,差异有统计学意义(P<0.05);SLE实验组IL-10为(53.73±6.35)pg/mL,明显高于对照组的(25.45±4.28)pg/mL,差异有统计学意义(P<0.05)。SLE活动组25-羟维生素D3为(14.42±8.43)ng/mL,明显低于缓解组的(21.23±8.52)ng/mL和对照组,差异有统计学意义(P<0.05);SLE活动组IL-10水平为(58.21±7.18)pg/mL,明显高于缓解组的(40.51±6.89)pg/mL和对照组,差异有统计学意义(P<0.05)。SLE患者血清25-羟维生素D3水平与SLEDAI呈负相关(P<0.05);SLE患者血清IL-10水平与SLEDAI呈正相关(P<0.05)。结论 25-羟维生素D3与IL-10在系统性红斑狼疮发病中起重要作用,并与疾病的活动度相关,具有重要临床应用价值。更多还原

【Abstract】 Objective To investigate the clinical application of 25-hydroxy vitamin D3(25-OHD3) and IL-10 in systemic lupus erythematosus(SLE). Methods 182 cases of patients with SLE were recruited as the experimental group,and 150 cases of non-SLE patients who came to the hospital during the same period as the normal health control group. There were no significances in genders and age between the 2 groups(P>0.05). The SLE group were further divided into the activity group(100 cases)and the remission group(82 cases)according to the disease activity index(SLEDAI)standard for evaluation. The levels of 25-hydroxy vitamin D3 and IL-10 in serum were measured by ELISA,and the results were analyzed among 3 groups. Results The level of 25-hydroxy vitamin D3 in the SLE experimental group was(17.51±8.29)ng/mL,which was significantly lower than that in the control group(38.31±9.34)ng/mL(P<0.05). The level of IL-10 in SLE experimental group was(53.73±6.35)pg/mL,which was significantly higher than that in the control group(25.45±4.28)pg/mL,(P<0.05). The level of 25-hydroxyl vitamin D3 in SLE activity group was(14.42±8.43)ng/mL,significantly lower than the remission group(21.23±8.52)ng/mL and control group,(P<0.05). The level of IL-10 in SLE activity group was(58.21±7.18)pg/mL was significantly higher than that in the remission group(40.51±6.89)pg/mL and control group,(P<0.05). The level of 25-hydroxyl vitamin D3 in serum of SLE patients was negatively correlated with SLEDAI(P<0.05). The level of serum IL-10 in SLE patients was positively correlated with SLEDAI(P<0.05). Conclusion 25-hydroxy vitamin D3 and IL-10 play an important role in the pathogenesis of systemic lupus erythematosus,and are related to the activity of the disease,suggesting a great potential in the clinical application.更多还原