【摘要】 目的探讨复发转移乳腺癌患者的首发转移模式和预后的影响因素。方法研究2013年1月1日~2015年6月31日我院收治的病理诊断的复发转移乳腺癌患者75例,对其首次复发转移模式和影响其预后确诊年龄、复发年龄、部位、淋巴结转移情况、HER-2状况、激素受体情况和转移器官部位数目、治疗手段的相关因素进行回顾性分析。结果最常见肿瘤转移部位为骨转移25例(33.33%),其次为肺转移17例(22.67%)。单因素分析显示,首次转移部位数目、淋巴结转移数目、HER-2情况及治疗手段和预后相关(P<0.05)。多因素分析显示,首次转移部位数目、淋巴结转移数目、HER-2情况、治疗手段是复发转移乳腺癌患者预后的独立影响因素(P<0.05)。结论乳腺癌患者术后首次复发转移部位常常为骨转移,其次为肺转移、肝转移。HER-2情况、首次复发转移器数目、淋巴结转移数目、治疗手段是影响复发转移乳腺癌患者的独立预后因素。更多还原

【Abstract】 Objective To investigate the influencing factors of the first metastatic pattern and prognosis of patients with recurrent metastatic breast cancer.Methods 75 patients with recurrent metastatic breast cancer diagnosed from January 1,2013 to June,31,2015 were studied for their first recurrence and metastasis patterns,and their age,recurrence age,location,lymph node metastasis,and HER-2 status.The factors related to hormone receptors,number of metastatic organs,and treatment methods were analyzed retrospectively. Results The most common tumor metastasis site was bone metastasis in 25 cases(33.33%),followed by lung metastases in 17 cases(22.67%).Univariate analysis showed that the number of first metastatic sites,number of lymph node metastases,HER-2 status, treatment methods,and prognosis were related(P <0.05).Multivariate analysis showed that the number of first metastatic sites,lymph node metastasis,HER-2 status,and treatment were independent predictors of prognosis in patients with recurrent metastatic breast cancer(P <0.05).Conclusion The first recurrence and metastasis site of breast cancer patients is usually bone metastasis,followed by lung metastasis and liver metastasis.The HER-2 condition,number of first recurrence metastases,number of lymph node metastases, and treatment methods are independent prognostic factors in patients with recurrent metastatic breast cancer.更多还原