【摘要】 目的研究雪莲培养物复方胶囊的免疫调节作用。方法雌性ICR小鼠192只,按体重随机分成对照组和0.20、0.40、1.20g/kg·bw 3个剂量组,小鼠经口灌胃给予受试物30d后,分别测定免疫功能的各项指标。结果雪莲培养物复方胶囊0.20、0.40、1.20g/kg·bw组小鼠的足趾肿胀度(0.35、0.39、0.41mm)明显高于对照组(0.24mm)(P <0.01),0.40、1.20g/kg·bw组小鼠的抗体生成细胞数(28.0、34.2×103/全脾)明显高于对照组(P <0.01)(18.5×103/全脾),0.20、0.40、1.20g/kg·bw组小鼠的血清溶血素(105.1、100.8、107.0)明显高于对照组(85.8)(P <0.01),0.40、1.20g/kg·bw组小鼠的NK细胞活性(52.2、51.9)明显高于对照组(39.9)(P <0.01)。结论雪莲培养物复方胶囊能增强小鼠的细胞免疫功能、体液免疫功能和NK细胞活性。更多还原

【Abstract】 Objective To explove the immunomodulatory effects of Saussurea Involucrataculture capsule. Methods A total of 192 female ICR mice were randomly divided into control group,0.20g/kg·bw,0.40g/kg·bw and 1.20g/kg·bw does groups by weight.Saussurea Involucrataculture capsule were orally given to the mice in different does groups for 30 days and then various indexes of immune system were determined. Results Tumefaction degree of mouse foot vola in 0.20,0.40,and 1.20g/kg·bw does groups(0.35,0.39,0.41mm) were statistically significant higher than that of the control group(0.24mm)(P <0.01).The number of antibody-producing cell in 0.40 and 1.20g/kg·bw does groups(28.0,34.2×103/whole spleen)were statistically significant higher than that of the control group(18.5×103/whole spleen)(P <0.01).The level of serum hemolysin in 0.20,0.40 and 1.20g/kg·bw does groups(105.1,100.8,107.0)were statistically significant higher than that of the control group(85.8)(P <0.01).The activity of NK cell in 0.40,1.20g/kg·bw does groups(52.2,51.9)were statistically significant higher than that of the control group(39.9)(P <0.01). Conclusion Saussurea Involucrata culture capsule can strengthen cellular immune functions,humoral immune functions,and the activity of NK cell of mice.更多还原