【摘要】 目的 了解我国2010-2017年发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)的流行特征。方法 对来源于“传染病报告信息管理系统”和“突发公共卫生事件信息管理系统”的数据进行描述性分析。用Cochran-Armitage趋势检验验证病死率随年龄变化趋势,不同组别的病死率差异采用卡方检验,检验水准取α=0.05。结果 2010-2017年,全国20个省331个县共报告确诊病例6 515例,死亡413人,病死率为6%。病例主要分布在河南、山东、湖北、安徽、浙江、辽宁、江苏等7省,病例数占全国总数的99%。4～10月为该病流行季,报告病例数占全年的98%。病例职业主要为农民,占87%。发病年龄主要集中在50～74岁,占病例总数的78%。病死率随年龄增长呈上升趋势,由45～49岁年龄组2%增加到≥80岁年龄组的12%。结论 SFTS在我国部分地区地方性流行,病例高度散发,发病时间集中在4～10月,主要发病人群为农民和中老年。接触病例血液是造成人际传播疫情的高危因素。高龄和误诊会增加病例病死的风险。更多还原

【Abstract】 Objective To describe epidemiological features of severe fever with thrombocytopenia syndrome(SFTS) in China from 2010 to 2017. Methods The data included for analysis come from national disease reporting information system and public health emergency information management system. Cochran-Armitage trend test is selected for testing the association between age groups and fatality rate. The chi-square test is used of testing the difference of fatality rate among different groups. It is considered statistically significant when P is less than 0.05. Results From 2010 to 2017, 6 515 lab-confirmed cases of SFTS and 413 fatal cases were reported in 331 counties of 20 provinces with a fatality rate of 6%. 99% of lab-confirmed cases were reported in Henan, Shandong, Hubei, Anhui, Liaoning,Zhejiang and Jiangsu. 98% of the lab-confirmed cases were reported from April to October, which were the peak seasons of SFTS. Farmers accounted for 87% of lab-confirmed cases, while 78% of the lab-confirmed cases were aged between 50 and 74 years. The fatality rate increased with age, rising from 2% of 45-49 years to 12% of ≥80 years.Conclusions SFTS were endemic in some areas of China. The SFTS cases’ geographical distribution was highly sporadic. The illness time of cases was focused from April to October, while farmers and elderly people have a high risk for illness. Contact with blood of cases is a risk factor for human to human transmission of SFTS. The old age and misdiagnosis would increase risk of fatality.更多还原