Effects of Composition of Ophiopogon Polysaccharide,Notoginseng total saponins and Rhizoma Coptidis Alkaloids on the Inflammatory Response of Atherosclerosis Rabbit Modle by Controlling p38MAPK
目的研究冬连三七组分(Composition of Ophiopogon polysaccharide,Notoginseng total saponins and Rhizoma Coptidis alkaloids CONR)调控AGEs/p38MAPK信号转导通路改善糖尿病动脉粥样硬化(diabetic atherosclerosis,DA)兔氧化应激反应。方法设立空白组、模型组、辛伐他汀组、CONR高剂量组、CONR低剂量组、SB203580组;脉推注四氧嘧啶并且配合腹主动脉内膜球囊损伤术诱导雄性纯种新西兰大白兔的DA模型,实验组分别每日给予CONR450 mg/kg、CONR 150 mg/kg;辛伐他汀3 mg/kg灌胃10周,12 h重复腹腔注射SB203580 2 mg/kg10周;正常组每日给予生理盐水20mL灌胃作为对照。结果实验各组对AGEs均有降低作用,对p-p38MAPK蛋白高表达均有抑制作用,与模型组比较差异有统计学意义。CONR高、低剂量组、辛伐他汀组对p-p38MAPK蛋白的抑制作用优于SB203580组(P<0.01),CONR高、CONR低剂量组、辛伐他汀组之间差异无统计学...
【英文摘要】
Objective The purpose of this study was to explore the effects of composition of Ophiopogon polysaccharide,Notoginseng total saponins and Rhizoma Coptidis alkaloids(CONR) on Oxidative stress reaction of diabetic atherosclerotic rabbit modle by interventing AGEs/p38 mitogen-acti-vatedproteinkinase(p38 MAPK) signal pathway. Methods Setting up blank group,model group,CONR high-dose group,CONR low-dose group,SB203580 group,simvastatin group.DA rabbits were established by alloxan intravenous injection with abdom...
【基金】
国家自然科学基金(81374026);
中国中医科学院名医名家传承项目(05-78)
【更新日期】
2018-10-24
【分类号】
R285.5
【正文快照】
were inhibited significantly compared with the model group (P<0.01). The inhibitory effect of p-p38MAPK protein in CONRhigh and low dose group,simvastatin group were better than that in SB203580 group (P <0.01). There was no statisticallysignificant diffe
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