AIM: To determine the primary target of nemonoxacin and mutation position in S. aureus by genomic characterization of first and second step mutants. METHODS: Quinolone resistance-determining region( QRDR) mutations of gyr A,gyr B,and grl A of resistant mutants were identified by PCR amplification and gene sequencing. RESULTS: All the 4 first step mutants selected using nemonoxacin contained changes at codon 86,439,and 440,but did not lead to amino acid substitution. For secondstep mutants selected from firs...
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