【摘要】 目的:研究中国社区健康老年人MRI上T2脑白质高信号的发生率、部位、严重程度与相关危险因素的关系。方法:共计156名中国上海单社区60岁以上健康老年人入组。分别进行常规体格检查和神经系统检查后,进行平扫MRI检查。根据T2脑白质高信号的部位分成脑室旁和深部白质/皮层下二个部位。严重程度依据Fazekas分级系统分成Ⅰ,Ⅱ,Ⅲ级。采用多元逻辑回归分析方法,统计脑白质高信号与危险因素的相关性。结果:77.6%和88.5%的社区健康老年人分别出现脑室旁白质高信号和深部白质高信号。调整其他变量后,年龄(OR,1.102;P=0.003)和高血压(OR,2.707;P=0.015)是脑室旁高信号的独立危险因素。年龄(OR,1.189;P<0.001)、肥胖(OR,2.977;P=0.015)和吸烟(OR,4.125;P=0.049)是深部白质高信号的独立危险因素。结论:中国社区健康老年人中,脑白质高信号常见,并随年龄增加而增加。血管病危险因素,如高血压、肥胖、吸烟和脑白质高信号明显相关,提示脑白质高信号形成原因是血管病变起源,这些结果和以往的研究一致。更多还原

【Abstract】 Purpose:White Matter Hyperintensity(WMH)-related findings in normal aging are rarely reported in China.This study investigated the prevalence and anatomical location of WMH and related risk factors in Chinese population of normal aging.Methods:A group of 156 healthy subjects aged over 60 years old in a community in Shanghai were enrolled.All participants received physical and neurological examinations and magnetic resonance imaging.Fazekas rating scale was used to describe the severity of periventricular hyper-intensity(PVH) and deep white matter hyper-intensity(DWMH).Multivariate logistic regression model were performed to examine the association of WMH and potential related factors.Results:PVH and DWMH appeared in 77.6% and 88.5% of the subjects respectively.Adjusted by other variables,age(OR,1.102;P=0.003) and hypertension(OR,2.707;P=0.015) were found as the independent risk factors of PVH.Independent risk factors for DWMH were age(OR,1.189;P<0.001),obesity(OR,2.977;P=0.015),and cigarette smoking(OR,4.125;P=0.049).Conclusion:Among Chinese normal aging,WMH is common and associated with aging.Consistent with numerous prior studies,vascular risk factors such as hypertension,obesity and cigarette smoking were also significantly associated with WMH burden which suggesting a possible vascular etiology.更多还原