Thirteen matrine derivatives were synthesized with high yield with one step in aqueous phase. The chemical structures of the synthesized compounds were characterized by ~1H NMR, ~(13)C NMR and HRMS. Three crystals of compound 13-(piperidin-1-yl)matrine(a), 13-(piperidin-1-yl)carbodithioate matrine(k) and 13-(morpholin-4-yl) carbodithioate matrine(m) were obtained and X-ray diffraction data showed that their structures included five chiral carbon atoms with the absolute configuration of 5(S), 6(S), 7(R), 11(...
【基金】
Project supported by the National Natural Science Foundation of China(No.21272144);
the Fundamental Research Funds for the Central Universities(Nos.1301030054;X2015YB06)~~
【更新日期】
2018-05-10
【分类号】
TQ464.4
【正文快照】
Matrine(1)is one of the major active alkaloids isolatedfrom Sophora alopecuroides L,which is a useful Chineseherbal drug.Matrine possesses good biological activities.Itnot only has been used for the treatment of lipopolysaccha-ride-induced liver injury,[1
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