Deep eutectic solvent based on L-proline and oxalic acid has been demonstrated for the first time as an efficient catalyst for synthesis of 4,7-dihydro-1 H-pyrazolo[3,4-b]pyridine-5-carbonitrile derivatives via one-pot three-component reaction of aldehyde, 3-oxopropanenitrile and 1 H-pyrazol-5-amine. The key features of this approach include the broad substrate scope, operational simplicity, recyclable catalyst and possibility to scale up giving multigram quantities.
【基金】
Project supported by the National Natural Science Foundation of China(No.21272053);
the Natural Science Foundation of Hebei Province(No.B2015205182)~~
【更新日期】
2018-05-10
【分类号】
O626
【正文快照】
1 IntroductionFrom the economical point of view and simplicity,mul-ticomponent reactions(MCRs)offer significant advantagesover conventional linear-type synthesis.MCRs are power-ful synthetic tools for the construction of a complex targetcompound with attr
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