【摘要】 目的探讨谷胱甘肽硫基转移酶(GST)基因多态性(GSTM1和GSTT1)与新生儿黄疸的关系。方法新生儿黄疸150例作为病例组,其总胆红素大于256.5μmol/L;选择无新生儿黄疸100例作为对照组。采用PCR法评估GSTM1与GSTT1基因型。应用Logistic多元回归分析两种基因突变对新生儿黄疸的影响。结果病例组GSTM1和GSTT1缺失型基因比例高于对照组(61.33%vs.47.00%和59.33%vs.46.00%)(P<0.05)。GSTM1和GSTT1基因突变是新生儿黄疸发生的高危因素[OR(95%CI)=2.56(1.32~5.89)和OR(95%CI)=2.14(1.14~2.60),P<0.05]。结论 GSTM1和GSTT1基因突变与新生儿黄疸的发病密切相关。更多还原

【Abstract】 Objective To explore the relationship between glutathione S-transferase(GST)gene polymorphism(GSTM1 and GSTT1)and neonatal jaundice.Methods The genotype of GSTM1 and GSTT1 was detected by PCR in 150 neonates with jaundice(total bilirubin>256.5μmol/L)(group A).One hundred neonates without jaundice were taken as the controls(group C).Logistic multiple regression was used to analyze the effects of two genetic mutations on neonatal jaundice.Results Proportions of the neonates with null genotype in GSTM1 and GSTT1 were higher in group A than those in group C(61.33% vs.47.00% and 59.33% vs.46.00%)(P<0.05).Genetic mutations of GSTM1 and GSTT1 were the high risk factors for the occurrence of neonatal jaundice[OR(95%CI)=2.56(1.32-5.89)and OR(95%CI)=2.14(1.14-2.60,P<0.05].Conclusion There is a close relationship between gene mutations of GSTM1 and GSTT1 and neonatal jaundice.更多还原