【摘要】 目的分析强戒所哨点吸毒人群丙肝(HCV)感染的特征,解释HCV变化趋势,为有针对性地制订性病艾滋病防治策略提供依据。方法收集成都市郫都区2011-2016年强戒所吸毒人群哨点监测数据,采用描述性统计方法分析HCV变化的特征,探索影响因素。结果 2 399名吸毒者中,HIV和HCV检出率分别为5. 6%(134例) 49. 1%(1 177例),其中,89. 6%(120/134)的HIV合并感染了HCV。口吸者HCV检出率从2011年的32. 2%(39/121)下降到2016年的6. 8%(20/295),口吸的比例从2011年的30. 3%(121/400)升至2016年的74. 4%(296/398)。注射吸毒者的HCV检出率保持在80%～90%之间,注射吸毒的比例从69. 8%(279/400)下降到25. 6%(102/398)。随着年龄的增加,口吸者的检出率从20岁以下组的9. 4%(3/32)快速上升至40岁及以上组的19. 4%(53/273);注射吸毒者除了20岁以下组是28. 6%(2/7)外,其余年龄组保持在80%以上。结论强戒所吸毒人群中,注射吸毒者的HCV检出率变化不明显,但样本人群中口吸者的占比逐年增加,以及口吸者HCV检出率呈下降趋势,导致当地HCV检出率逐年下降,提示当地艾滋病防治工作需根据这种变化调整干预策略。更多还原

【Abstract】 Objective To analyze the characteristics of HCV infection among drug users recruited from drug rehabilitation center,explore the causes of changes over the years,and obtain evidence for formulating targeted strategies for prevention and treatment of STD and AIDS.Methods Sentinel surveillance data of drug users performed in drug rehabilitation center between 2011 and2016 years in Pidu district,Chengdu city were collected.Descriptive statistical methods were applied in analyzing the characteristics of HCV changes over the years. Results Among 2 399 drug users,the detection rates of HIV and HCV were 5. 6%( 134 cases) and 49. 1%( 1 177 cases),respectively,and most of HIV-infected drug users( 89. 6%,120/134) were infected with HCV. The detection rate of HCV in oral drug users dropped from32. 2%( 39/121) in 2011 to 6. 8%( 20/295) in 2016,and the proportion of oral drug users increased from30. 3%( 121/400) in 2011 to 74. 4%( 296/398) in 2016. The detection rate of HCV in injection drug users( IDU) was above 80% in any years,and the proportion of injection drug users dropped from 69. 8%( 279/400) to 25. 6%( 102/398). With the increase of age,the detection rate of HCV in oral drug users increased rapidly from 9. 4%( 3/32) in<20 years old group to 19. 4%( 53/273) in 40 years old group. In injection drug users,the detection rate was 28. 6%( 2/7) in the <20 years old group and above 80% in all other age groups.Conclusion Among those drug users,the detection rate of HCV in IDU has not changed significantly,but the proportion of oral drug user in the sample increased year by year,and the detection rate of HCV showed decreasing trend. This phenomenon has resulted in decrease of detection rate since 2011,indicating that strategies of AIDS prevention and treatment need to be adjusted according to this change.更多还原