【摘要】 目的:探讨FAS-670 A> G基因多态性与宫颈癌发病风险的关联。方法:于Pubmed、知网等数据库中全面检索相关文献,收集2016年12月前公开发表的相关文献,使用Stata12. 0进行meta分析。结果:经过严格标准筛选,最终纳入本次meta分析的研究共13项,累计病例3146例,对照3070例。共记录4种模式:纯合子(GG vs AA);显性模式(AG+GG vs AA);隐性模式(GG vs AA+AG);等位基因(G vs A)。在各模式中,meta分析的OR值及95%置信区间分别为1. 00 (0. 78-1. 28); 1. 05 (0. 84-1. 32); 1. 02 (0. 84-1. 25); 1. 02(0. 91-1. 15),且按种族进行亚组分析中各OR值均无统计学意义。结论:FAS-670 A> G基因多态性与宫颈癌发病风险之间无显著性关联。更多还原

【Abstract】 Objective: In order to Explore the association between FAS-670 A > G polymorphism and the risk of cervical cancer. Methods: the relevant articles published before December 2016 was retrieved from the database of Pubmed and CNKI,and the meta analysis was carried out by Stata12. 0. Results: Thirteen studies,which contended 3146 cases and 3070 controls in total,were finally selected through executing rigid standards. By considering the wild type genotype( AA) or allele( A) as the reference,the ORs and 95% CIs were calculated separately for4 genetic models: homozygous( GG vs AA),dominant( AG + GG vs AA),recessive model( GG vs AA + AG)and allele contrast( G vs A). In overall meta-analysis,the pooled Ors and their 95% confidence intervals were1. 00( 0. 78-1. 28); 1. 05( 0. 84-1. 32); 1. 02( 0. 84-1. 25); 1. 02( 0. 91-1. 15). Also with the subgroup analysis,there are no significant differences in all models. Conclusion: The FAS-670 A > G polymorphism might not contribute to the susceptibility of cervical cancer.更多还原