【摘要】 目的研究SIRT1蛋白在胃癌组织中的表达情况及其与肿瘤组织学分化、分期和转移等临床病理参数之间的关系。方法采用免疫组织化学SP法检测SIRT1蛋白在74例胃癌组织和20例正常胃黏膜组织中的表达水平。结果 SIRT1在胃癌组织中的表达阳性率为47.3%(35/74),显著高于正常胃黏膜组织的20.0%(4/20),差异有统计学意义(χ2=4.83, P <0.05)。SIRT1的阳性表达与胃癌患者的性别、年龄、肿瘤直径以及组织学分化无关(P>0.05),而与肿瘤分期和淋巴结转移相关(P <0.05)。结论 SIRT1在胃癌组织的表达上调,且与肿瘤分期、淋巴结转移相关,有望成为胃癌治疗的潜在新靶点。更多还原

【Abstract】 Objective To investigate the expression of SIRT1 in gastric carcinoma and the relationship between its expression and clinical pathological parameters(tumor differentiation, stage, metastasis, etc). Methods The expression of SIRT1 was detected by immunohistochemistry in 74 cases of gastric carcinomas tissues and 20 cases of normal gastric mucosa tissues. Results The positive rate of SIRT1 in gastric carcinoma tissues(47.3%, 35/74) was significantly higher than that of normal gastric mucosa tissues(20.0%, 4/20), with statistical difference(χ2= 4.83, P <0.05). The expression of SIRT1 in patients with gastric carcinoma was closely correlated with the tumor stage and lymph node metastasis(P <0.05), but was irrelevant to gender, age, tumor diameter and tumor differentiation(P >0.05). Conclusions The over expression of SIRT1 in gastric carcinoma tissues correlates with tumor stage and lymph node metastasis, and SIRT1 is expected to become a potential new target for the treatment of gastric carcinoma.更多还原